SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE This article indicates that neither the VNTR in the promoter of the MAOA gene, nor rs25531 in the gene encoding 5-HTT, is involved in SIDS. 24286237 2014
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 AlteredExpression disease BEFREE Using qRT-PCR we studied the gene expression of 5-HTT in ten SIDS cases, previously analyzed at a molecular level and which showed the genetic S/S profile. 22771822 2013
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE Despite its functional role, results highlight the usefulness of 5HTT as a valuable tracer of SIDS risk in IALTE infants. 22711722 2012
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS. 20661167 2010
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants. 18810510 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE One of the candidate genes is the serotonin transporter (5-HTT) gene, based on decreased serotonergic receptor binding observed in the brain-stems of SIDS victims. 19261524 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease MGD Overall, our findings provide i) new insights into the role of SERT gene in SIDS, and ii) the first in vivo validation of the molecular mechanism involving the activation of TGF-beta1 signalling in the cardiac fibrosis. 19646988 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS. 18477062 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease LHGDN Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. 18387780 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS. 18477062 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE 5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS. 17077377 2006
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN 3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis. 16691588 2006
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease CTD_human These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12599191 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 AlteredExpression disease BEFREE These data, if confirmed in larger studies, may begin to explain the differences in SIDS incidence by ethnicity, suggest a role for levels of 5-HTT expression in generation of SIDS susceptibility, and provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease GENOMICS_ENGLAND These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12599191 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE In our recent study allele variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS). 12018976 2002
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS). 11335745 2001
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE However, very few studies have so far focused on the degree to which rare variants of SLC6A4 are responsible for the depression observed in adolescent and young adult suicide patients. 31629822 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE Antidepressants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (SSRIs) improve mood in adults but have paradoxical long-term effects when administered during perinatal periods, increasing the risk to develop anxiety and depression. 30279456 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE The reviewed findings support the involvement of sleep in the interaction between 5-HTTLPR and stress in depression. 31181376 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE <b>Results:</b> 5-HTTLPR was associated with depression in PD patients and presence of the LL genotype was protective against the depression risk. 31024427 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 AlteredExpression disease BEFREE Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTLPR moderated associations between low levels of positive parenting at 11-13 years and subsequent depression at 17-19 years. 29094757 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Subgroup analyses showed that most studies found BDNF and SLC6A4 hypermethylations to be associated with MDD or depression in general. 30718449 2019