Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50).
|
27909246 |
2017 |
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
|
24819384 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, patients harboring mutations in components of the WASH complex could be at risk for developing type 2 diabetes.
|
30425062 |
2019 |
Diarrhea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Increasing achievement of multiple WASH targets together was associated with a lower odds of pupils having diarrhea (<i>P</i> trend < 0.01) and having respiratory symptoms (<i>P</i> trend < 0.01), but was not associated with roll-call absence (<i>P</i> trend = 0.14) or pupil-reported absence (<i>P</i> trend = 0.41).
|
28093534 |
2017 |
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The Washington University in St. Louis Kiddie-Schedule for Affective Disorders and Schizophrenia (WASH-U KSADS) was administered to children (AR) who had at least one parent with BPD (N=36) and children of healthy parents (HC) (N=27), by raters who were blind to diagnostic category.
|
16698037 |
2007 |
Signs and Symptoms, Respiratory
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Increasing achievement of multiple WASH targets together was associated with a lower odds of pupils having diarrhea (<i>P</i> trend < 0.01) and having respiratory symptoms (<i>P</i> trend < 0.01), but was not associated with roll-call absence (<i>P</i> trend = 0.14) or pupil-reported absence (<i>P</i> trend = 0.41).
|
28093534 |
2017 |
Malnutrition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The causes of undernutrition are often linked to inadequate access to water, sanitation and hygiene services but limited evidence exists on the direct association between poor WASH practices and children's' nutritional statuses.
|
31500268 |
2019 |
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
|
28399507 |
2017 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
WASH regulates the trafficking of endosomal α5β1 integrin to the plasma membrane and is fundamental for integrin-driven cell morphology changes and integrin-mediated cancer cell invasion.
|
22114305 |
2011 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
MTSS1 expression led to a marked reduction in levels of functional cortacin (pcortactin Y421), an actin nucleation-promoting factor that has a crucial role in cancer cell invasion and metastasis.
|
28068324 |
2017 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MTSS1 expression led to a marked reduction in levels of functional cortacin (pcortactin Y421), an actin nucleation-promoting factor that has a crucial role in cancer cell invasion and metastasis.
|
28068324 |
2017 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
MTSS1 expression led to a marked reduction in levels of functional cortacin (pcortactin Y421), an actin nucleation-promoting factor that has a crucial role in cancer cell invasion and metastasis.
|
28068324 |
2017 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
WASH regulates the trafficking of endosomal α5β1 integrin to the plasma membrane and is fundamental for integrin-driven cell morphology changes and integrin-mediated cancer cell invasion.
|
22114305 |
2011 |
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we designed a cluster-randomized controlled trial to study the efficacy of two educational-plus-therapeutic interventions in the reduction of anemia: one in nutrition and the other in WASH/Malaria.
|
30764549 |
2019 |
Borderline Personality Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Washington University in St. Louis Kiddie-Schedule for Affective Disorders and Schizophrenia (WASH-U KSADS) was administered to children (AR) who had at least one parent with BPD (N=36) and children of healthy parents (HC) (N=27), by raters who were blind to diagnostic category.
|
16698037 |
2007 |
Bronchopulmonary Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Washington University in St. Louis Kiddie-Schedule for Affective Disorders and Schizophrenia (WASH-U KSADS) was administered to children (AR) who had at least one parent with BPD (N=36) and children of healthy parents (HC) (N=27), by raters who were blind to diagnostic category.
|
16698037 |
2007 |
Malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we designed a cluster-randomized controlled trial to study the efficacy of two educational-plus-therapeutic interventions in the reduction of anemia: one in nutrition and the other in WASH/Malaria.
|
30764549 |
2019 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MTSS1 expression led to a marked reduction in levels of functional cortacin (pcortactin Y421), an actin nucleation-promoting factor that has a crucial role in cancer cell invasion and metastasis.
|
28068324 |
2017 |
Tunga penetrans infestation
|
0.010 |
Biomarker
|
disease |
BEFREE |
There is a clear role for public health workers to expand the WASH policy to include washing of feet with soap in school-aged children to fight tungiasis and to raise awareness of the importance of sealed floors.
|
31095558 |
2019 |
Mood Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The Washington University in St. Louis Kiddie-Schedule for Affective Disorders and Schizophrenia (WASH-U KSADS) was administered to children (AR) who had at least one parent with BPD (N=36) and children of healthy parents (HC) (N=27), by raters who were blind to diagnostic category.
|
16698037 |
2007 |
Neurodevelopmental Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.
|
26365382 |
2015 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Phosphorylation of the actin nucleation-promoting factor and actin-stabilizing protein cortactin downstream of the epidermal growth factor receptor-Src-Arg kinase cascade is known to be a critical trigger for invadopodium maturation and subsequent cell invasion in breast cancer cells.
|
28356423 |
2017 |
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Overexpression of HSBP1 in breast tumors is associated with increased levels of WASH complexes and with poor prognosis for patients.
|
29844016 |
2018 |