|
Brain Ischemia
|
0.210 |
Biomarker
|
disease |
BEFREE |
These new data from ncx2-/- and ncx3-/- mice may open new experimental avenues for the development of effective therapeutic compounds that, by selectively inhibiting or activating these molecular targets, could treat patients affected by cognitive impairment including Alzheimer's, Parkinson's, Huntington's diseases, and infarct dementia.More importantly, knockout and knockin mice also provided new relevant information on the role played by NCX in maintaining the intracellular Na(+) and Ca(2+) homeostasis and in protecting neurons during brain ischemia.
|
23224882 |
2013 |
|
Brain Ischemia
|
0.210 |
Biomarker
|
disease |
RGD |
Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.
|
16107787 |
2006 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Na+/Ca2+ exchanger subtype (NCX1, NCX2, NCX3) protein expression in the rat hippocampus following 3 min and 8 min durations of global cerebral ischemia.
|
18037393 |
2008 |
|
Status Epilepticus
|
0.200 |
Biomarker
|
disease |
RGD |
Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus.
|
15461673 |
2004 |
|
Brain Waves
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Human brain arousal in the resting state: a genome-wide association study.
|
29703947 |
2019 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that SLC8A2 might be a glioma tumor suppressor gene and detected the role of SLC8A2 in glioblastoma and explored the underlying molecular mechanism.
|
29047259 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Surprisingly, NCX2 could be activated by addition of the DNA methylation inhibitor 5-aza-2'-deoxycytidine to glioma cell lines in which NCX2 was completely silent.
|
20132488 |
2010 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Except for three known intragenic single nucleotide polymorphisms, rs12459087, rs7259674 and rs8104926, no NCX2 sequence variations were detected in any of the tumour samples.
|
20132488 |
2010 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) isoforms NCX1 and NCX2 activity.
|
31073288 |
2019 |
|
Cerebral Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Anti-excitotoxic effects of cannabidiol are partly mediated by enhancement of NCX2 and NCX3 expression in animal model of cerebral ischemia.
|
27856160 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
|
29047259 |
2017 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Since SLC8A2 is broadly expressed in brain and plays a potential role during embryonic development, its haploinsufficiency could possibly be related to mental retardation; as it is also expressed in aortic and intestinal smooth muscles, SLC8A2 could be related to the aortic defect of the complex cardiac malformation and to the megacolon.
|
19022414 |
2009 |
|
Deformity
|
0.010 |
Biomarker
|
group |
BEFREE |
Since SLC8A2 is broadly expressed in brain and plays a potential role during embryonic development, its haploinsufficiency could possibly be related to mental retardation; as it is also expressed in aortic and intestinal smooth muscles, SLC8A2 could be related to the aortic defect of the complex cardiac malformation and to the megacolon.
|
19022414 |
2009 |