Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
NKCC1 is an electroneutral neuronal Cl<sup>-</sup> importer and the dominance of NKCC1 function has been proposed as the common pathology for HIE seizures, TLE, autism, and schizophrenia.
|
31068771 |
2019 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Together, these preclinical and clinical results suggest that variation in NKCC1 may increase risk for schizophrenia via alterations of mRNA expression at the molecular level and impairment of optimal prefrontal function at the macro or systems level.
|
24695712 |
2014 |
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Together, these preclinical and clinical results suggest that variation in NKCC1 may increase risk for schizophrenia via alterations of mRNA expression at the molecular level and impairment of optimal prefrontal function at the macro or systems level.
|
24695712 |
2014 |
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and 2 SNPs in these genes linked to mRNA expression interactively increase schizophrenia risk.
|
23921125 |
2013 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
This study shows that two SNPs in intergenic of the CTXN3 and SLC12A2 genes, rs245178 and rs698172, are associated with risk of schizophrenia in Thai population.
|
22643131 |
2012 |
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
This study shows that two SNPs in intergenic of the CTXN3 and SLC12A2 genes, rs245178 and rs698172, are associated with risk of schizophrenia in Thai population.
|
22643131 |
2012 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Furthermore, DISC1 and NKCC1 interact epistatically to affect risk for schizophrenia in two independent case control studies.
|
22385968 |
2012 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
We examined the expression of transcripts derived from three genes related to GABA signaling [GAD1 (GAD67 and GAD25), SLC12A2 (NKCC1), and SLC12A5 (KCC2)] in the prefrontal cortex (PFC) and hippocampal formation of a large cohort of nonpsychiatric control human brains (n = 240) across the lifespan (from fetal week 14 to 80 years) and in patients with schizophrenia (n = 30-31), using quantitative RT-PCR.
|
21795557 |
2011 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.
|
20819979 |
2011 |
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
To compare the levels of NKCC1, KCC2, OXSR1, STK39, WNK1, WNK3, and WNK4 transcripts in prefrontal cortex area 9 between subjects with schizophrenia and healthy comparison subjects.
|
20819979 |
2011 |
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
An increased expression of NKCC1 and mutations of the gene have been associated with schizophrenia.
|
21237234 |
2011 |