SLC20A1, solute carrier family 20 member 1, 6574

N. diseases: 87; N. variants: 1
Disease: Vascular calcification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 AlteredExpression phenotype BEFREE Additionally, the Pit‑1 protein level may be a novel index for evaluating the magnitude of VC in CKD patients. 30896801 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 AlteredExpression phenotype BEFREE RAGE, through the modulation of Pit-1 expression, is a key molecule in the genesis of VC. 30778553 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 Biomarker phenotype BEFREE Pit-1 should be considered as a promising index of VC. 30651873 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 AlteredExpression phenotype BEFREE In conclusion, gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway. 28686724 2017
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 AlteredExpression phenotype BEFREE Medial VC was significantly augmented by HPi+HiCa medium compared with HPi alone (300%, p＜0.05), and was associated with upregulation of Pit-1 protein. 27840385 2017
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 Biomarker phenotype BEFREE Magnesium prevents phosphate-induced vascular calcification via TRPM7 and Pit-1 in an aortic tissue culture model. 28123180 2017
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 Biomarker phenotype BEFREE We investigated the in vivo requirement for PiT-1 in vascular calcification using a mouse model of chronic kidney disease and the potential compensatory role of PiT-2 using in vitro knockdown and overexpression strategies. 23968976 2013
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.080 Biomarker phenotype BEFREE Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1. 20664908 2010