|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Changes in ETT parameters and RA characteristics may contribute to improvement of several VR indexes such as cQTd, cJT and Tp-e intervals at the end of CR.
|
30177313 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) of Solute carrier family 22, member 4 (SLC22A4) have been shown to be associated with several autoimmune diseases, including Crohn's disease (CD) and rheumatoid arthritis (RA).
|
26329403 |
2015 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Accordingly, SLC22A4 was associated with joint erosion in not-very-longstanding RA, although RA susceptibility association was weak and its clinical significance was uncertain.
|
25707686 |
2015 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
An atlas of genetic influences on human blood metabolites.
|
24816252 |
2014 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Overall, this study provided evidence that SLC22A4 gene polymorphisms played important roles in the etiology of RA in the largest Asian population, the Chinese population.
|
24599653 |
2014 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, although the mechanism is not clear, single nucleotide polymorphisms of OCTN1 and OCTN2 genes are associated with increased incidences of rheumatoid arthritis, Crohn's disease and asthma.
|
22952014 |
2013 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.
|
18087673 |
2008 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis.
|
18709696 |
2008 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Data of the current study do not confirm the universal and population independent susceptibility role of the SLC22A4 C6607T and RUNX1 G24658C variants for rheumatoid arthritis; furthermore, the data presented here show, that there are no significant carnitine-metabolism associated functional consequences of the different genotypes evidenced by the lack of detectable differences in the carnitine ester profiles.
|
18328148 |
2008 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
No influence of SLC22A4 C6607T and RUNX1 G24658C genotypic variants on the circulating carnitine ester profile in patients with rheumatoid arthritis.
|
18328148 |
2008 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis.
|
18709696 |
2008 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three specific single-nucleotide polymorphisms (SNPs) have been reported to associate with RA and CD and to change the functional activity of two organic cation transporters, solute carrier family 22 member 4/5 (SLC22A4) and (SLC22A5).
|
16484987 |
2006 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The SLC22A4 and RUNX1 polymorphisms described as etiological in the Japanese study did not show a significant role in RA susceptibility in our population.
|
16652416 |
2006 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to RA in the Spanish population.
|
16821265 |
2006 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In particular, a functional single-nucleotide polymorphism (SNP) mapping to intron 1 of the organic cation transporter 1 (OCTN1; SLC22A4) gene was associated with RA in a Japanese population, and a haplotype of a different SNP in the same gene and one in an adjacent gene, OCTN2 (SLC22A5), was associated with CD.
|
15751072 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants of the SLC22A4 gene are associated with susceptibility to rheumatoid arthritis and Crohn's disease.
|
15795384 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, it has been shown that multiple genetic variants in one pathway (both in a transcription factor, RUNX-1, as in the transcription factor binding site of RUNX1 in the SLC22A4 gene) can each confer very small risks but by gene-gene interactions can confer a ninefold risk for rheumatoid arthritis.
|
15838240 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5) in RA and Crohn's disease (CD); programmed cell death 1 (PDCD1) in systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), and RA; and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in T1D, RA, and SLE.
|
15883854 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The SLC22A4 gene has also been associated with rheumatoid arthritis.
|
16255050 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We used a case-control approach to investigate the prevalence of these variants in a Canadian RA cohort and to determine whether RA and Crohn's disease share SLC22A4 susceptibility alleles.
|
15693005 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.
|
15184985 |
2004 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
LHGDN |
SLC22A4 and RUNX1: identification of RA susceptible genes.
|
15184985 |
2004 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis.
|
15245375 |
2004 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
|
14608356 |
2003 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder.
|
14608356 |
2003 |