Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
The increased incidence of the disease in young women, the familial cases, the association with autoimmune disorders, and the recent discovery that mutation of the PPH1 gene may not be restricted to familial PPH support the hypothesis that the development of pulmonary hypertension likely implies an individual susceptibility or predisposition, which is probably genetically determined.
|
11590841 |
2001 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives.
|
12358323 |
2002 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Bone morphogenetic protein receptor 2 mutations in pulmonary hypertension.
|
11893684 |
2002 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
These results indicate that a substantial portion of Japanese PPH patients carry BMPR2 mutations with considerable heterogeneity.
|
15146475 |
2004 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
Identification of a novel mutation in the gene for bone morphogenetic protein receptor II in an Israeli patient with familial primary pulmonary hypertension.
|
15055271 |
2004 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
Primary pulmonary hypertension in children may have a different genetic background than in adults.
|
15295086 |
2004 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension.
|
15775752 |
2005 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
LHGDN |
BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways.
|
15516492 |
2005 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension.
|
15965979 |
2005 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Simvastatin enhances bone morphogenetic protein receptor type II expression.
|
16297860 |
2006 |
Pulmonary Hypertension
|
0.370 |
GeneticVariation
|
phenotype |
LHGDN |
A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension.
|
18364108 |
2008 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
|
20522807 |
2010 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
We describe the case of an 83-year-old man with a family history of pulmonary hypertension (PH) who presented with severe pulmonary arterial hypertension (PAH) and later tested positive for a novel bone morphogenetic protein receptor 2 (BMPR2) gene mutation.
|
20496075 |
2010 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.
|
23502781 |
2013 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension.
|
24224048 |
2013 |
Pulmonary Hypertension
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Our study suggests that exposure with a mild Th2 antigen can trigger pulmonary hypertension on the background of the expression of a hypomorphic BMPR2 gene and that conversely, the expression of the hypomorphic BMPR2 gene can alter the immune response to a mild, inhaled antigen.
|
23383100 |
2013 |