Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson's disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB) as the second most frequent cause of dementia after Alzheimer's disease and multiple system atrophy.
|
29370097 |
2018 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We show that NUCB1 inhibits aggregation of islet-amyloid polypeptide associated with type 2 diabetes mellitus, a-synuclein associated with Parkinson's disease, transthyretin V30M mutant associated with familial amyloid polyneuropathy, and Aβ42 associated with Alzheimer's disease by stabilizing their respective protofibril intermediates.
|
28220836 |
2017 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.
|
26111745 |
2015 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analysed the expression of two β-synuclein transcript variants and the main α-synuclein transcript SNCA140, in frozen samples of three areas from brains of patients with (i) pure diffuse Lewy body pathology; (ii) pure Alzheimer's disease pathology; (iii) diffuse Lewy body pathology and concomitant Alzheimer's disease pathology and (iv) controls.
|
20959308 |
2010 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of the superior temporal cortex, a region selectively affected in LBD and AD, showed that compared to controls, levels of alpha-synuclein were increased in cases of diffuse LBD (DLBD), levels of beta-synuclein were decreased in AD and DLBD, and levels of gamma-synuclein were increased in AD cases.
|
11578596 |
2001 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCSG1 has a great sequence homology with the Alzheimer's disease related neural protein synuclein (SNC); thus, it was also named SNC-gamma.
|
9973226 |
1999 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Members of the synuclein gene family are potential candidates for the risk of AD.
|
10081980 |
1999 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of alpha-synuclein as the first of the loci involved in Parkinson's disease and the identification of this protein in pathological deposits in other disorders has led to the suggestion that it may share pathogenic mechanisms with multiple system atrophy, Alzheimer's disease and prion disease and that these mechanisms are related to a synuclein pathway to cell death.
|
10469843 |
1999 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel and highly conserved presynaptic protein has been independently described in rodents (synuclein/SYN-1), songbirds (synelfin), and humans (the precursor protein of the non-A beta component of senile plaques, NACP); a fragment of the latter has been detected in senile plaques in Alzheimer's disease (AD).
|
8759778 |
1996 |
Alzheimer's Disease
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Further studies are required to investigate the implication of the NACP/synuclein gene in Alzheimer disease.
|
7601450 |
1995 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 140 amino acid protein is identical with the precursor of the non-A beta component of Alzheimer's disease amyloid which in turn is highly homologous to synuclein from Torpedo electroplaques and rat brain.
|
8194594 |
1994 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synuclein proteins and Alzheimer's disease.
|
7530877 |
1994 |