|
Mental Depression
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson's disease (PD) serve as a good example and are potentially linked to other pathological PD features such as progressive dopaminergic neuron cell death, behavioral defects, and nonmotor symptoms like anosmia, cognitive impairment, and depression.
|
30482039 |
2019 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
BEFREE |
A significantly higher α-synuclein burden was observed in the substantia nigra (P = 0.006), ventral tegmental area (P = 0.011) and nucleus accumbens (P = 0.031) in LBD patients with depression.
|
30582885 |
2019 |
|
Mental Depression
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<i>SNCA</i> mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment.
|
31027150 |
2019 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
BEFREE |
Results showed that the patients with lower α-synuclein presented more complaints on post-concussion symptoms and depression.
|
31040769 |
2019 |
|
Mental Depression
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although in comparison to IPD, SNCA duplication carriers have the most similar course of disease, even for duplication carriers the frequencies of dementia, hallucinations, and depression seem higher than in IPD.
|
28802919 |
2017 |
|
Mental Depression
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To investigate possible associations of Parkinson's disease (PD) with polymorphism in depression-related genes and in the alpha-synuclein (SNCA) gene.
|
28320136 |
2017 |
|
Mental Depression
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Stepwise logistic regression model found that female sex, UPDRS part II score, motor fluctuation, GBA L1444P and SNCA Rep-1 variants collectively best predict depression in PD.
|
27745782 |
2016 |
|
Mental Depression
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that AAV-mediated α-synuclein overexpression in dopamine neurons is not only useful to model motor impairments of PD, but also depression.
|
26363495 |
2015 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
BEFREE |
Parkinson's disease, neuropathologically defined by the aggregation of α-synuclein, is characterized by neuropsychiatric symptoms such as depression and anxiety preceding the onset of motor symptoms.
|
26201615 |
2015 |
|
Mental Depression
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The associations of hyposmia with SNCA variants and disease phenotypic characteristics including motor symptoms (UPDRS motor score) and other common NMSs (clinical possible RBD-cpRBD, depression and chronic constipation) were analyzed.
|
25921825 |
2015 |
|
Mental Depression
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The patients carrying the SNCA triplication developed early-onset parkinsonism combined with depression, behavior disturbances, sleep disorders, and cognitive decline; marked autonomic dysfunctions were not observed.
|
26077166 |
2015 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
BEFREE |
NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans.
|
21271299 |
2011 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
RGD |
Here we sought to determine if alpha-Syn, or the other synuclein family members, beta-synuclein (beta-Syn) and gamma-synuclein (gamma-Syn), modulate NET activity in an animal model of depression, the Wistar-Kyoto (WKY) rat.
|
18800064 |
2009 |
|
Mental Depression
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders.
|
18799894 |
2008 |