Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
4-Acetyl-Antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 re-Expression.
|
30103475 |
2018 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
MnSOD is reduced in a variety of tumor types and has been proposed to be a new kind of tumor suppressor gene, but the mechanism(s) by which MnSOD suppresses malignancy is unclear.
|
10919671 |
2000 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
SOD2 is a key enzyme in the conversion of reactive oxygen species and has been implicated in a host of disease states, including cancer.
|
17192397 |
2007 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MnSOD gene polymorphism association with steroid-dependent cancer.
|
18553161 |
2009 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
SOD2 is a C-myc target gene that promotes the migration and invasion of tongue squamous cell carcinoma involving cancer stem-like cells.
|
25578561 |
2015 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A bioinformatics analysis of clinical cancer genomic data revealed that matrix metalloproteinase (MMP)1 and three markers of oxidative stress - superoxide dismutase 2, NADPH oxidase 4, and carbonic anhydrase 9 - are upregulated in human mesenchymal GBM cancer tissue, and that MMP1 is positively correlated to all three of these oxidative stress markers.
|
31715381 |
2020 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
A family of AP-2 proteins down-regulate manganese superoxide dismutase expression.
|
11278550 |
2001 |
Malignant Neoplasms
|
0.400 |
Therapeutic
|
group |
CTD_human |
A family of AP-2 proteins down-regulate manganese superoxide dismutase expression.
|
11278550 |
2001 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A valine (Val) to alanine (Ala) substitution at amino acid 9, mapping within the mitochondrion-targeting sequence of the MnSOD gene, has been associated with an increased cancer risk.
|
18023606 |
2008 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
|
27343087 |
2016 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Background.Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders.
|
26881045 |
2016 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.
|
26543228 |
2016 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Collectively, our findings reveal a novel TLR2-SOD2 axis as a potential biomarker for therapy and prognosis in cancer.
|
30536754 |
2019 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Combination of the SOD2 gene silencing therapy and conventional radiotherapy should be attempted to improved cancer therapy for NPC.
|
20204285 |
2010 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Complete sequencing and oxidative modification of manganese superoxide dismutase in medulloblastoma cells.
|
19676086 |
2009 |
Malignant Neoplasms
|
0.400 |
Therapeutic
|
group |
CTD_human |
Complete sequencing and oxidative modification of manganese superoxide dismutase in medulloblastoma cells.
|
19676086 |
2009 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Experimental and epidemiological evidence supporting a conflicting role of SOD2 in tumor biology, and epidemiological evidence that SOD2 and GPX1 can interact to affect cancer risk and progression indicated that it is the net accumulation of mitochondrial H<sub>2</sub>O<sub>2</sub> (mtH<sub>2</sub>O<sub>2</sub>) resulting from of the balance between the activities SOD2 and anti-oxidants such as GPX1 that determines whether SOD2 prevents or promotes oncogenesis.
|
28087256 |
2017 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, SOD1 activity, CS activity, SOD1 expression, GPX4 expression, and GPX4 protein level were inversely correlated with the malignancy, whereas catalase activity, catalase protein, SOD2 protein level, and the SOD2:CS ratio were positively correlated with the degree of malignancy.
|
29862858 |
2018 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Hazard ratios for 8 additional SNPs in CYP2E1, GPx2, SOD1, and SOD2, though not statistically significant, were suggestive of differences in allele hazards for all-cause and/or cancer death.
|
23632049 |
2013 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, the wide variation in Mn-SOD and MT mRNA levels among normal subjects may reflect different susceptibilities to diseases including cancer.
|
14503839 |
2003 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the past two decades, research has established that SOD2 transcriptional activity is controlled, at least in part, via epigenetic mechanisms at different stages in the development of human cancer.
|
22946823 |
2013 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Insights into the Dichotomous Regulation of SOD2 in Cancer.
|
29099803 |
2017 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Reconstitution of MnSOD expression in several human cancer cell lines leads to reversion of malignancy and induces a resistant phenotype to the cytotoxic effects of TNF and hyperthermia.
|
11165872 |
2001 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Reconstitution of MnSOD expression in several human cancer cell lines leads to reversion of malignancy and induces a resistant phenotype to the cytotoxic effects of TNF and hyperthermia.
|
11165872 |
2001 |
Malignant Neoplasms
|
0.400 |
Therapeutic
|
group |
CTD_human |
Reconstitution of MnSOD expression in several human cancer cell lines leads to reversion of malignancy and induces a resistant phenotype to the cytotoxic effects of TNF and hyperthermia.
|
11165872 |
2001 |