SOD2, superoxide dismutase 2, 6648

N. diseases: 668; N. variants: 32
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 Biomarker disease BEFREE Concurrently, the level of mitochondrial antioxidant enzymes of superoxide dismutase 2 (SOD2) and peroxiredoxin 1 and 4 (p1 and p4) along with protein and DANA oxidation were examined to in postmortem brains of AD (n= 8) and normal (n= 7) subjects to evaluate the metabolism dysfunction role in AD pathology. 29473507 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 AlteredExpression disease BEFREE Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus. 29710707 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 Biomarker disease BEFREE For these reasons, we designed a study of the variability in GSTT1, GSTM1, and MnSOD genes in healthy and AD groups from a Venezuelan population. 25542503 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 GeneticVariation disease BEFREE Although the T allele of the SOD2 rs4880 SNP gene (rs4880-T) is not an independent risk for aMCI or AD, this allele increases the risk to aMCI patients carrying at least one APOEε4 allele. 26696693 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 Biomarker disease CTD_human Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. 19374891 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 Biomarker disease BEFREE We discuss the importance of our findings and the relevance of SOD2 to AD risk. 17376152 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 GeneticVariation disease LHGDN We discuss the importance of our findings and the relevance of SOD2 to AD risk. 17376152 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 Biomarker disease BEFREE Whereas reductions in Sod2 would be expected to trigger or exacerbate neuronal and vascular pathology in AD, increasing Sod2 activity might be of therapeutic benefit. 16687508 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 GeneticVariation disease BEFREE Our data suggest that the Ala-9Val polymorphism in the MnSOD gene is not associated with genetic susceptibility in AD patients. 16485861 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.380 AlteredExpression disease BEFREE We therefore determined the protein SOD-1 and SOD-2 levels in the brains of controls (n = 9) and adult patients with DS (n = 9) and Alzheimer disease (AD; n = 9). 11217146 2001