SOD2, superoxide dismutase 2, 6648

N. diseases: 668; N. variants: 32
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 AlteredExpression group BEFREE Enzymatic activity and deacetylation level of SOD2 were significantly reduced in hypertension-EPCs, which was accompanied with decreased SIRT3 expression. 31189433 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 AlteredExpression group BEFREE We also studied the expression of Sirt1, which regulates eNOS expression and Sirt3, which regulates SOD2 expression as possible epigenetic targets of enzyme expression involved in the long- term programming of hypertension. 30717220 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 AlteredExpression group BEFREE SOD2 acetylation had an inverse correlation with SOD2 activity and a direct correlation with the severity of hypertension. 28684630 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 GeneticVariation group BEFREE The risk of hypertension among the individuals harboring both the ALDH2*2 allele and the SOD2 Val/Val genotype was significantly higher in drinkers than in nondrinkers (adjusted odds ratio, 6.22; 95% confidence interval, 2.26-17.1; P<0.001). 23111423 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group CTD_human Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness. 21593737 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 GeneticVariation group BEFREE We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. 21053180 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group RGD Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. 16716903 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.550 Biomarker group CTD_human Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. 11834524 2002