|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Together, carrying allele G in the single nucleotide polymorphism (rs2070424 A/G) in SOD1, or allele C in the single nucleotide polymorphism (rs4880 T/C) in SOD2, enhances genetic susceptibility to Parkinson's disease.
|
31601079 |
2019 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, in order to investigate a possible interaction between oxidative stress and α-synuclein aggregation in vivo, a transgenic model of PD with haplodeficiency for SOD2 was generated on the basis of the well-characterized murine (Thy-1)-h[A30P]-α-synuclein transgenic line.
|
29718367 |
2018 |
|
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A significantly increased activities of SOD, Cu/ZnSOD, GST and reduced GR activity and an increase of MDA concentration were observed in the striatum of PD rats, comparing to the control group, combined with a significantly reduced activities of GR,SOD, Cu/ZnSOD and an increased GPX activity and MDA concentration in the hippocampus, a significantly lower GR, SOD, MnSOD, Cu/ZnSOD, and GST activities in the cerebral cortex.
|
29068596 |
2017 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.
|
25279756 |
2014 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.
|
25279756 |
2014 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate a novel pathway by which the P209A defect in the PINK1 kinase domain inhibits oxidative stress-induced HO-1 and SOD2 induction, which may accelerate the neurodegeneration in PD with PINK1 defect.
|
23261939 |
2013 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the possible interplay between DA and SOD2 in the pathogenesis of PD using enzymatic essays, site-specific mutagenesis, and optical and high-field-cw-EPR spectroscopies.
|
22723845 |
2012 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease.
|
20501330 |
2010 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.
|
18353766 |
2008 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Moreover, among subjects exposed to pesticide, the combined MnSOD/NQO1 variant genotype was significantly associated with a 4.09-fold increased risk of PD (95%CI, 1.34-10.64, P=0.0052).
|
17188257 |
2007 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, among subjects exposed to pesticide, the combined MnSOD/NQO1 variant genotype was significantly associated with a 4.09-fold increased risk of PD (95%CI, 1.34-10.64, P=0.0052).
|
17188257 |
2007 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, both alleles of the Ala9Val polymorphism in the MTS of MnSOD were equally distributed between German PD patients and controls excluding this gene variant as a risk factor for PD in Caucasian subjects.
|
10049782 |
1999 |
|
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mn SOD activity and protein in a patient with chromosome 6-linked autosomal recessive parkinsonism in comparison with Parkinson's disease and control.
|
9371904 |
1997 |