Congestive heart failure
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Our results provide evidence that defective SOD2 may lead to toxic increases in the levels of damaging oxygen radicals in the neonatal heart, which can result in rapidly developing heart failure and death.
|
31494578 |
2020 |
Congestive heart failure
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Curcumin-treated HF mice displayed enhanced exercise performance compared with vehicle-treated HF mice; 2) both soleus (Sol) and extensor digitorum longus (EDL) muscles of HFrEF mice exhibited reduced force and rapid fatigue, which were ameliorated by curcumin; and 3) protein expression of Nrf2, hemeoxygenase-1, SOD2, myogenin, and MyoD were significantly lower, but total ubiquitinated proteins, MURF1, and atrogen-1 were higher in Sol and EDL of HFrEF compared with sham mice, whereas these alterations in Nrf2 signaling and antioxidant defenses in HFrEF were attenuated by curcumin, which had no effect on cardiac function per se in mice with severe HFrEF.
|
30462567 |
2019 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
BEFREE |
Publisher Correction: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.
|
30498227 |
2018 |
Congestive heart failure
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
MID in HF was associated with preserved activity of respiratory chain enzymes but reduced activity of aconitase and citrate synthase (by -26% and -15%, P < 0.05) and reduced expression of catalase, glutathione peroxidase, and superoxide dismutase 2.
|
27647766 |
2017 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
BEFREE |
MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.
|
29116107 |
2017 |
Congestive heart failure
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Eplerenone alone increased the production of NO, MnSOD and CuZnSOD activity, arginase I gene and protein expression, and mannose receptor gene and protein expression, but decreased mineralocorticoid activity only in “heart failure” macrophages.
|
24486397 |
2014 |
Congestive heart failure
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Known epigenetic changes contributing to CVD include hypomethylation in proliferating vascular smooth muscle cells in atherosclerosis, changes in estrogen receptor-α (ER-α) and ER-β methylation in vascular disease, decreased superoxide dismutase 2 expression in pulmonary hypertension (PH), as well as trimethylation of histones H3K4 and H3K9 in congestive heart failure.
|
23480168 |
2013 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
CTD_human |
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.
|
21284947 |
2011 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
CTD_human |
This study examined telomere biology in heart/muscle-specific manganese superoxide dismutase-deficient mice (H/M-SOD2(-/-)), which develop progressive congestive heart failure and exhibit pathology typical of dilated cardiomyopathy.
|
21195081 |
2011 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
CTD_human |
Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy.
|
16155095 |
2005 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
CTD_human |
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium.
|
16105639 |
2005 |
Congestive heart failure
|
0.570 |
Biomarker
|
disease |
MGD |
|
|
|
Heart failure
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Our results provide evidence that defective SOD2 may lead to toxic increases in the levels of damaging oxygen radicals in the neonatal heart, which can result in rapidly developing heart failure and death.
|
31494578 |
2020 |
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
BEFREE |
Enzymatic activity and deacetylation level of SOD2 were significantly reduced in hypertension-EPCs, which was accompanied with decreased SIRT3 expression.
|
31189433 |
2019 |
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
BEFREE |
We also studied the expression of Sirt1, which regulates eNOS expression and Sirt3, which regulates SOD2 expression as possible epigenetic targets of enzyme expression involved in the long- term programming of hypertension.
|
30717220 |
2019 |
Heart failure
|
0.550 |
Biomarker
|
disease |
BEFREE |
Publisher Correction: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.
|
30498227 |
2018 |
Heart failure
|
0.550 |
Biomarker
|
disease |
BEFREE |
MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.
|
29116107 |
2017 |
Heart failure
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
MID in HF was associated with preserved activity of respiratory chain enzymes but reduced activity of aconitase and citrate synthase (by -26% and -15%, P < 0.05) and reduced expression of catalase, glutathione peroxidase, and superoxide dismutase 2.
|
27647766 |
2017 |
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
BEFREE |
SOD2 acetylation had an inverse correlation with SOD2 activity and a direct correlation with the severity of hypertension.
|
28684630 |
2017 |
Heart failure
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Eplerenone alone increased the production of NO, MnSOD and CuZnSOD activity, arginase I gene and protein expression, and mannose receptor gene and protein expression, but decreased mineralocorticoid activity only in “heart failure” macrophages.
|
24486397 |
2014 |
Hypertensive disease
|
0.550 |
Biomarker
|
group |
CTD_human |
Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies.
|
25101153 |
2014 |
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
The risk of hypertension among the individuals harboring both the ALDH2*2 allele and the SOD2 Val/Val genotype was significantly higher in drinkers than in nondrinkers (adjusted odds ratio, 6.22; 95% confidence interval, 2.26-17.1; P<0.001).
|
23111423 |
2013 |
Heart failure
|
0.550 |
Biomarker
|
disease |
CTD_human |
Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice.
|
21195081 |
2011 |
Heart failure
|
0.550 |
Biomarker
|
disease |
CTD_human |
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.
|
21284947 |
2011 |