Fatigue
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Rats were subjected to a treadmill running that was interrupted at three different moments: (1) at the early phase, when minimal heat dissipation occurred due to tail vasoconstriction and the tail skin temperature (T<sub>skin</sub>) reached its nadir; (2) at the steady-state phase, when both the T<sub>skin</sub> and core body temperature (T<sub>core</sub>) plateaued at a high level (~ 20 min); and (3) at fatigue, when T<sub>core</sub> and T<sub>skin</sub> were still elevated. c-Fos expression in the medial and ventromedial preoptic areas (mPOA and vmPOA), median preoptic nucleus (MnPO), paraventricular and supraoptic nucleus (PVN and SON), and septohypothalamic nucleus (SHy) was determined.
|
31399877 |
2019 |
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.
|
30680470 |
2019 |
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.
|
30680470 |
2019 |
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.
|
30680470 |
2019 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data furthermore suggest a possible role of Dbp5/DDX19 in alternative translation termination events, such as during stress response or in developmental processes, which classifies the helicase as a potential drug target for nonsense suppression therapy to treat cancer and neurodegenerative diseases.
|
30873535 |
2019 |
Renal cyst
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Detailed phenotyping of 14 patients with SON haploinsufficiency identified kidney anomalies in 8 patients, including horseshoe kidney, unilateral renal hypoplasia, and renal cysts.
|
31005274 |
2019 |
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Herein, we describe seven unrelated individuals with de novo variants in SON and propose that deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies.
|
27545676 |
2016 |
Congenital thrombocytopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SON is located within 21q22.11, a critical region for Braddock-Carey syndrome, which is characterized by congenital thrombocytopenia, intellectual disability, micrognathia, and a distinctive facies.
|
27256762 |
2016 |
Developmental delay (disorder)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Herein, we describe seven unrelated individuals with de novo variants in SON and propose that deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies.
|
27545676 |
2016 |
Thrombocytopenia Robin sequence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we suggest that the intellectual disability observed in Braddock-Carey syndrome could be accounted for by haploinsufficiency of SON.
|
27256762 |
2016 |
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis.
|
24789761 |
2015 |
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis.
|
24789761 |
2015 |
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, SON DNA binding protein (SON) was found to be important for normal trafficking of influenza virions to late endosomes early in infection.
|
20081832 |
2010 |
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knock-down of SON by siRNA resulted in significant growth arrest, and disruption of the interaction between AML1-ETO and endogenous SON rescued cells from AML1-ETO-induced growth arrest, suggesting that SON is an indispensable factor for cell growth, and AML1-ETO binding to SON may trigger signals inhibiting leukemogenesis.
|
18952841 |
2008 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In nude mice bearing hTERT-expressing MCF-7 xenografts, tumor radioactivity uptake of (99m)Tc-MAG3-ASON after injection was significantly higher than that of (99m)Tc-MAG3-SON after injection (P < 0.05).
|
18006621 |
2007 |
leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.
|
26990989 |
2016 |
Childhood Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.
|
26990989 |
2016 |
leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we investigate the role of 2 AML1-ETO C-terminal-interacting proteins, N-CoR, a transcriptional corepressor, and SON, a splicing/transcription factor required for cell cycle progression, in AML1-ETO-induced leukemia development.
|
23426948 |
2013 |
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we investigate the role of 2 AML1-ETO C-terminal-interacting proteins, N-CoR, a transcriptional corepressor, and SON, a splicing/transcription factor required for cell cycle progression, in AML1-ETO-induced leukemia development.
|
23426948 |
2013 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.
|
30680470 |
2019 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Our data furthermore suggest a possible role of Dbp5/DDX19 in alternative translation termination events, such as during stress response or in developmental processes, which classifies the helicase as a potential drug target for nonsense suppression therapy to treat cancer and neurodegenerative diseases.
|
30873535 |
2019 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Our data furthermore suggest a possible role of Dbp5/DDX19 in alternative translation termination events, such as during stress response or in developmental processes, which classifies the helicase as a potential drug target for nonsense suppression therapy to treat cancer and neurodegenerative diseases.
|
30873535 |
2019 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with café-au-lait spots.
|
30680470 |
2019 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis.
|
24789761 |
2015 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis.
|
24789761 |
2015 |