|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SORLA protein levels in cancer cell lines and bladder cancers correlates with HER2 levels.
|
31138794 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SORLA protein levels in cancer cell lines and bladder cancers correlates with HER2 levels.
|
31138794 |
2019 |
|
Carotid Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis.
|
30550937 |
2019 |
|
Cerebral Amyloid Angiopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene.
|
31092209 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The identification of the relatively unknown HSPA12A as a SorLA specific interaction partner could lead to novel insight into the molecular mechanism of SorLA, and re-emphasises the role of heat shock proteins in neurodegenerative diseases.
|
30679749 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SORLA protein levels in cancer cell lines and bladder cancers correlates with HER2 levels.
|
31138794 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exploring the sortilin related receptor, SorLA, in depression.
|
29499509 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exploring the sortilin related receptor, SorLA, in depression.
|
29499509 |
2018 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer disease associated variants in SORL1 accelerate dementia development in Parkinson disease.
|
29567423 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Exploring the sortilin related receptor, SorLA, in depression.
|
29499509 |
2018 |
|
Dementia in Parkinson's disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results show the first association of the AD risk factor SORL1 with incident dementia in PD, providing new evidence that AD related disease mechanisms may contribute to dementia in a subset of patients with PD.
|
29567423 |
2018 |
|
Hypercholesterolemia, Familial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble LR11 associates with aortic root calcification in asymptomatic treated male patients with familial hypercholesterolemia.
|
28637586 |
2017 |
|
Age-related cognitive decline
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The SORL1 gene rs1699102 polymorphism has been found to be associated with age-related cognitive decline and GMV reduction of the right middle temporal pole in older adults.
|
27779372 |
2017 |
|
Epiretinal Membrane
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble form of LR11 is highly increased in the vitreous fluids of patients with idiopathic epiretinal membrane.
|
28102455 |
2017 |
|
Vascular calcification
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We assessed the relation between the circulating soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11), a risk factor for cardiovascular disease, and vascular calcification in asymptomatic statin-treated heterozygous FH patients.
|
28637586 |
2017 |
|
Multiple Myeloma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Further analysis revealed that DNA methylation was involved in regulating SORL1 expression in MM.
|
27811368 |
2016 |
|
Pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of LR11 in pulmonary arterial hypertension was investigated using mouse and cell models of induced hypoxia.
|
27493099 |
2016 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of LR11 in pulmonary arterial hypertension was investigated using mouse and cell models of induced hypoxia.
|
27493099 |
2016 |
|
Brain atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we explored the effect of SORL1 genotypes on AD-related brain atrophy.
|
27177090 |
2016 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These include ANK3, SORL1 and a region of chromosome 6p containing several genes implicated in schizophrenia and bipolar disorder.
|
25897833 |
2015 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We investigated the involvement of LR11 and sLR11 in CVD development in FH patients and in LDLR deficient (Ldlr(-/-)) mice.
|
26520897 |
2015 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These include ANK3, SORL1 and a region of chromosome 6p containing several genes implicated in schizophrenia and bipolar disorder.
|
25897833 |
2015 |
|
Huntington Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of SORLA expression results in impaired neuritic transport of TrkB and in blunted response to BDNF in primary neurons; and it aggravates neuromotoric deficits caused by low BDNF activity in a mouse model of Huntington's disease.
|
23977241 |
2013 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LR11 is specifically expressed in monocytes, and surface levels on leukemic cells are highly induced in both AML and ALL. sLR11 levels of acute leukemia patients were significantly increased (P<0.001) (ALL, 73.5±93.5 ng/ml; AML, 26.8±29.1 ng/ml) in comparison to controls (9.2±3.3 ng/ml).
|
22750733 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LR11 is specifically expressed in monocytes, and surface levels on leukemic cells are highly induced in both AML and ALL. sLR11 levels of acute leukemia patients were significantly increased (P<0.001) (ALL, 73.5±93.5 ng/ml; AML, 26.8±29.1 ng/ml) in comparison to controls (9.2±3.3 ng/ml).
|
22750733 |
2012 |