Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Abnormal social behavior
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Abnormality of vision
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cerebral cortical atrophy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Agitation, CTCAE 5.0
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Memory Impairment, CTCAE 5.0
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Possible involvement of LR11 in the cellular proliferation sheds new light on the recently proposed novel functions of the LDL receptor gene family in atherosclerosis.
|
11425040 |
2000 |
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Possible involvement of LR11 in the cellular proliferation sheds new light on the recently proposed novel functions of the LDL receptor gene family in atherosclerosis.
|
11425040 |
2000 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, such proliferation-dependent expression of LR11 could be observed in a cultured neuroblastoma cell line, which was established to be a suitable in vitro model for proliferation and differentiation.
|
11425040 |
2000 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, such proliferation-dependent expression of LR11 could be observed in a cultured neuroblastoma cell line, which was established to be a suitable in vitro model for proliferation and differentiation.
|
11425040 |
2000 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, such proliferation-dependent expression of LR11 could be observed in a cultured neuroblastoma cell line, which was established to be a suitable in vitro model for proliferation and differentiation.
|
11425040 |
2000 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains.
|
15313836 |
2004 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains.
|
15313836 |
2004 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
|
16174740 |
2005 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.
|
16565469 |
2006 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We hypothesize that LR11 loss may be specific to sporadic AD and influence amyloid pathology through mechanisms independent of substrate-enzyme interactions regulated by FAD mutations.
|
16957580 |
2006 |
Familial Alzheimer Disease (FAD)
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease.
|
16957580 |
2006 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome.
|
17826910 |
2007 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.
|
17220890 |
2007 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several individual SNPs and SNP haplotypes were significantly associated with AD in this prospectively collected community-based cohort, confirming the previously reported positive association of SORL1 with AD.
|
17420311 |
2007 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
These results provide an independent replication of the association between AD and SORL1.
|
18090307 |
2007 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.
|
17220890 |
2007 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
LR11 levels in MCI were intermediate between no cognitive impairment and AD.
|
17721864 |
2007 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor.
|
18160637 |
2007 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results provide an independent replication of the association between AD and SORL1.
|
18090307 |
2007 |