Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two variants in SORL1 and TREM2 were identified that were associated with Alzheimer's disease.
|
31217084 |
2020 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Hereby we review the evidence of the association of SORL1 common and rare variants with AD risk and conduct a meta-analysis of published data on SORL1 rare variants in five large sequencing studies.
|
30911827 |
2019 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive screening for point mutations was carried out by direct sequencing of coding regions in the three known AD causative genes: PSEN1, PSEN2, APP, as well as the AD associated gene SORL1.
|
30636737 |
2019 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
SorLA has recently attracted much attention as a novel strong risk gene for Alzheimer's disease, and much effort is currently being put into understanding the underlying molecular mechanism.
|
30679749 |
2019 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the association between polymorphisms in several cholesterol-related genes [APOA5 (rs662799), APOC1 (rs11568822), APOD (rs1568565), CH25H (rs13500), LDLR (rs5930), SORL1 (rs2282649)] and AD in a cohort of Turkish patients.
|
30684189 |
2019 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
SORL1 processes a causal involvement in Alzheimer's disease (AD) as a proposed modulator of the amyloid precursor protein (APP).
|
31092209 |
2019 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between SORL1 polymorphisms and the risk of Alzheimer's disease.
|
29036834 |
2018 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results show the first association of the AD risk factor SORL1 with incident dementia in PD, providing new evidence that AD related disease mechanisms may contribute to dementia in a subset of patients with PD.
|
29567423 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Derivation of induced pluripotent stem cells TUSMi006 from an 87-year old Chinese Han Alzheimer's disease patient carrying GRINB and SORL1 mutations.
|
30077089 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer's disease (AD).
|
30078640 |
2018 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Decreased SorLA levels have been correlated to Alzheimer's disease, and omega-3 fatty acid supplementation is known to increase SorLA expression in neuronal cell lines and mouse models.
|
29660442 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The SORL1 gene encodes a protein involved in the amyloidogenic process, and its variants have been associated with Alzheimer's disease (AD) physiopathology.
|
29376855 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results from lipid metabolism arrays validated upregulation of several processes implicated in the biogenesis of β-amyloid and Alzheimer's disease (AD), including sterol o-acyltransferase 1/acetyl-coenzyme A acyltransferase 1 (SOAT1/ACAT1), sortilin-related receptor L1 (SORL1) and low-density lipoprotein receptor-related protein 12 (LRP12).
|
30390000 |
2018 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
More common SORL1 variants (ExAC-MAF≥1 × 10<sup>-5</sup>) were not associated with increased AD risk, even when predicted strongly damaging.
|
28537274 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Sex-specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure.
|
27535807 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The sorting-related receptor gene (SORL1) has been defined as an interesting candidate gene for Alzheimer's disease (AD).
|
26873856 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found one SORL1 RNA transcript strongly regulated by SORL1-BDNF interactions in elderly without pathological AD and showing stronger associations with diffuse than neuritic Aβ plaques.
|
28322202 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Sortilin-related receptor with LDLR class A repeats (SORLA, SORL1, or LR11) is a genetic risk factor associated with Alzheimer's disease (AD).
|
29114064 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The finding of three SORL1-variants that segregate with disease in three separate families with EOAD supports the involvement of SORL1 in AD pathology.
|
28595629 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity.
|
27911290 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results indicate that 6-shogaol should be regarded as an SORL1 activator and a potential preventive agent for the treatment of AD.
|
28188785 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
|
26732597 |
2017 |