|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Enrichr analysis resulted in the identification of SRY-related HMG-box gene 2 (SOX2) as a potential repressor that causes decrease in the expression of AdPC specific genes in NEPC.
|
31772313 |
2020 |
|
Bone Cysts, Aneurysmal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All components consistently showed diffuse p16, p63 and SOX2, variable cytokeratin (CK)7 and CK17 and rare Ber-EP4 and MYB expression; there was a substantially lower Ki67 index in pure ABCs and the ABC-like components.
|
31393622 |
2020 |
|
Exfoliation Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Evaluation of TUNEL, PCNA and SOX2 Expressions in Lens Epithelial Cells of Cataract Patients with Pseudoexfoliation Syndrome.
|
31424957 |
2020 |
|
Congenital defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mutations in the key transcription factor, SOX2, alone account for 20% of anophthalmia (no eye) and microphthalmia (small eye) birth defects in humans - yet its regulation is not well understood, especially on the post-transcription level.
|
31814023 |
2020 |
|
Childhood Germ Cell Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate.
|
31583686 |
2020 |
|
Disseminated Malignant Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our findings demonstrate that tumor-suppressor proteins Oct4 and SOX2 have a prominent expression profile in the primary stage of cancer, but, in the metastatic stage, their expression is downregulated, leading to the failure to prevent metastatic cancer.
|
31646784 |
2020 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
circ_0005273 promotes thyroid carcinoma progression by SOX2 expression.
|
31693489 |
2020 |
|
Fleck corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fibroblasts were obtained from the skin biopsies of patients with FCD (n = 2) and controls (n = 2). iPSCs were generated by exposing the fibroblasts to viral vectors that contained the Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC genes) responsible for promoving cell reprogramation.
|
31816405 |
2020 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of SOX2 reversed ChlA-F inhibition of cell invasion ability in human bladder cancer cells, suggesting that SOX2 is a major target of ChlA-F during its inhibition of human BC invasion.
|
31243344 |
2020 |
|
Adult Germ Cell Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate.
|
31583686 |
2020 |
|
Congenital arteriovenous malformation
|
0.010 |
Biomarker
|
disease |
BEFREE |
EC-specific suppression of Sox2 normalized endothelial differentiation and lumen formation and improved the cerebral AVMs.
|
31232700 |
2019 |
|
Merkel cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition.
|
31527246 |
2019 |
|
Lambert-Eaton Myasthenic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC.
|
30445363 |
2019 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further show that inhibition of OGT delayed initiation of pancreatic tumors by inhibition of Sox2.
|
31281487 |
2019 |
|
Pituitary Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX 2 Expression in Human Pituitary Adenomas-Correlations With Pituitary Function.
|
30587606 |
2019 |
|
Thymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In IHC results, SOX2 (HR: 7.57, P = 0.001) and IGF-1 (HR: 9.43, P = 0.001) expression levels in TC were significantly higher than those in TM.
|
31097100 |
2019 |
|
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our data demonstrated a chronic pain-induced nociceptive neurogenesis in DRG from Sox2-positive satellite cells, indicating a possible contribution of DRG neurogenesis to the pathology of chronic pain.
|
30648289 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of miR-196a decreased transwell invasiveness, sphere formation, transendothelial invasion, and Slug, Twist, Oct4, and Sox2 expression, suppressed angiogenesis, and reduced sizes of xenotransplants and number of pulmonary metastasis.
|
31614906 |
2019 |
|
Thymic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In IHC results, SOX2 (HR: 7.57, P = 0.001) and IGF-1 (HR: 9.43, P = 0.001) expression levels in TC were significantly higher than those in TM.
|
31097100 |
2019 |
|
Neurologic Symptoms
|
0.010 |
Biomarker
|
group |
BEFREE |
SOX2 antibodies are specific (>90%) markers for SCLC, but are rarely found in patients with other tumours, whether neurological symptoms are present or not.
|
30445363 |
2019 |
|
Adrenocorticotropic hormone (ACTH) deficiency (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX2-negative tumors were significantly associated with corticotrophin deficiency (p=0.047) and gonadotrophin deficiency (p=0.041).
|
30587606 |
2019 |
|
Paraneoplastic Cerebellar Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC.
|
30445363 |
2019 |
|
Nijmegen Breakage Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Human fibroblasts cells from a female diagnosed with Nijmegen Breakage Syndrome (NBS) carrying the homozygous NBN c.657_661del5 mutation were used to generate integration-free induced pluripotent stem cells (iPSCs) by over-expressing episomal-based plasmids harbouring OCT4, SOX2, NANOG, KLF4, c-MYC and LIN28.
|
30616142 |
2019 |
|
Tongue Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma.
|
31552166 |
2019 |
|
Equilibration disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results suggested that Sox2 is a potential target for generating Type I HCs, which may be important for regenerative strategies for balance disorders.
|
31678344 |
2019 |