SOX2, SRY-box transcription factor 2, 6657

N. diseases: 503; N. variants: 23
Disease: Bladder Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 AlteredExpression disease BEFREE The present study revealed that ISO could inhibit stem cell-like phenotypes and invasivity of human bladder cancer (BC) by specific attenuation of expression of CD44 but not SOX-2, at both the protein transcription and degradation levels. 31222373 2020
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 Biomarker disease BEFREE The <i>lnc-LBCS</i>-hnRNPK-EZH2-SOX2 regulatory axis may represent a therapeutic target for clinical intervention in chemoresistant bladder cancer. 30397178 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 Biomarker disease CTD_human Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. 29396848 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 Biomarker disease BEFREE RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer. 28182001 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 Biomarker disease BEFREE Our data show that Sox2 is a marker of bladder CSCs and indicate it as a potential clinical target for BCa therapy. 28793245 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 AlteredExpression disease BEFREE Epithelial-mesenchymal transition promotes SOX2 and NANOG expression in bladder cancer. 28240746 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.360 AlteredExpression disease BEFREE In addition, the expression level of Cripto-1 in bladder cancer was also found to be significantly associated with SRY-related HMG-box gene 2 expression (P = 0.003) and Ki-67 (P = 0.001). 25326807 2015