SOX2, SRY-box transcription factor 2, 6657

N. diseases: 503; N. variants: 23
Disease: Malignant neoplasm of brain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease BEFREE In addition, PHF20L1 may regulate the stability of SOX2 through its malignant brain tumor (MBT) domain, since the degradation of SOX2 is accelerated by UNC1215 and UNC669, inhibitors that bind to the MBT domain. 30089852 2018
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease CTD_human A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. 27935819 2017
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain 		0.320 Biomarker disease BEFREE Our results not only revealed the genetic plasticity contributing to drug resistance and stemness but also demonstrated the dominant role of SOX2 in maintenance of GBM CSCs, which may provide a novel therapeutic target to overcome the conundrum of poor survival of brain cancers. 27530866 2016