Colon Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
TIPE1 overexpression significantly inhibits colon cancer cell growth both in vitro and in vivo through impairing stemness, accompanied with downregulation of the stemness-related markers, ALDH, CD133, CD44, and SOX-9.
|
31111874 |
2020 |
Malignant tumor of colon
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
TIPE1 overexpression significantly inhibits colon cancer cell growth both in vitro and in vivo through impairing stemness, accompanied with downregulation of the stemness-related markers, ALDH, CD133, CD44, and SOX-9.
|
31111874 |
2020 |
Squamous cell carcinoma of esophagus
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Here, we independently confirmed the increased SOX9 expression in two ESCC cohorts and its correlation with poor prognosis.
|
31600529 |
2020 |
cervical cancer
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Analyses performed under logistic model, linear mixed model, and model incorporating correlations identified nine significant associations with three gynecologic diseases including four novel findings (rs79219469:C > T, LINC02183, P = 3.3 × 10<sup>-8</sup> and rs567534295:C > T, BRCA1, P = 3.1 × 10<sup>-8</sup> with OC, rs150806792:C > T, INS-IGF2, P = 4.9 × 10<sup>-8</sup> and rs140991990:A > G, SOX9, P = 3.3 × 10<sup>-8</sup> with UCC).
|
31488892 |
2020 |
Kidney Failure, Acute
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, mice deficient in Paneth cells (SOX9 Villin Cre mice) have reduced plasma norepinephrine levels after ischemic AKI.
|
31813250 |
2020 |
Nodule
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Increase in dsDNA content (p < 0.0005), up-regulation of RUNX2, ALPL, SPP1 (p < 0.0005) and SOX9 (p < 0.005) gene expression, and more calcium nodule formation (p < 0.0005) were observed in d3D cultures in comparison to s3D ones over time.
|
31506241 |
2020 |
Esophageal Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Deregulation of SOX9 in esophageal cancer has been reported.
|
31600529 |
2020 |
Esophageal carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Deregulation of SOX9 in esophageal cancer has been reported.
|
31600529 |
2020 |
Malignant neoplasm of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
Deregulation of SOX9 in esophageal cancer has been reported.
|
31600529 |
2020 |
Dejerine-Sottas Disease (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sox9 transcription factor, however, was significantly downregulated in the uPA-deficient/DSS-treated mice that developed colon adenomas as compared to the wild-type/DSS-treated group with no neoplasia identified.
|
31758376 |
2020 |
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increasing expression of SOX9 decreased adipogenic potential of AML-MSCs and decreased their ability to support AML progenitor cells.
|
31492897 |
2020 |
Osteoporosis, Postmenopausal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SNP rs73354570 of SOX9 was significantly associated with PMOP in both discovery stages (OR 1.24 [1.10-1.39], P = 3.56 × 10<sup>-4</sup>, χ<sup>2</sup> = 12.75) and combined samples (OR 1.25 [1.15-1.37], P = 5.25 × 10<sup>-7</sup>, χ<sup>2</sup> = 25.17).
|
31732751 |
2020 |
DOSAGE-SENSITIVE SEX REVERSAL
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sox9 transcription factor, however, was significantly downregulated in the uPA-deficient/DSS-treated mice that developed colon adenomas as compared to the wild-type/DSS-treated group with no neoplasia identified.
|
31758376 |
2020 |
Necrotizing enterocolitis in fetus OR newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
Organoid growth rate was significantly lower in NEC liver organoids compared to control liver organoids. mRNA expression of liver progenitor cells markers of LGR5 and SOX9 was lower in NEC liver organoids compared to control liver organoids.
|
31365937 |
2020 |
CAMPOMELIC DYSPLASIA
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study.
|
30712880 |
2019 |
CAMPOMELIC DYSPLASIA
|
1.000 |
Biomarker
|
disease |
BEFREE |
The data identify a novel molecular mechanism of disease in CD in which the truncated protein leads to a distinct and more significant effect on SOX9 function.
|
31389106 |
2019 |
Pierre Robin Syndrome
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study.
|
30712880 |
2019 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, SOX9 was identified as a transcription factor of FOXA1 in lung cancer and involved in affecting the expression of FOXA1 targeted genes-Bcl2, CDKN1B, RPRM and NKX2.
|
31221478 |
2019 |
Ovotesticular Disorders of Sex Development
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
A duplication upstream of SOX9 associated with SRY negative 46,XX ovotesticular disorder of sex development: A case report
|
31476840 |
2019 |
Gonadal Dysgenesis
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
We have shown a decreased SOX9-Phospho protein expression in the dysgenetic gonads of the patients with homozygous PPP2R3C variants suggesting impaired SOX9 signaling in the pathogenesis of gonadal dysgenesis.
|
30893644 |
2019 |
Hypospadias
|
0.120 |
Biomarker
|
disease |
BEFREE |
In conclusion, SOX9, which was regulated by both miR-145 and miR-145/MAPK signaling, could be involved in the pathogenesis of hypospadias.
|
30565690 |
2019 |
Scoliosis, unspecified
|
0.110 |
Biomarker
|
disease |
BEFREE |
To study the SOX9 mutation in CVM patients is of great significance to explain the pathogenesis of scoliosis (the clinical manifestation of CVM) and to explore the pathogenesis of SOX9-related skeletal deformities.
|
31549955 |
2019 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
IMPLICATIONS: SOX9/FXYD3/Src axis is critical for promoting CSC function and tamoxifen resistance in ER<sup>+</sup> breast cancer.
|
30206184 |
2019 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-190 increased the anti-estrogen sensitivity of breast cancer cells both in vitro and in vivo. miR-190 inhibited Wnt/β-catenin signaling by targeting SOX9, and its expression inversely correlated with that of SOX9 in breast cancer samples.
|
30658681 |
2019 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For clinical relevance, high SOX9 and HDAC5 expression are associated with lower survival rates in breast cancer patients treated with tamoxifen.
|
31690832 |
2019 |