|
Malignant desmoplastic melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Normal Expression of SRY-related HMG-BOX Gene 10 (SOX-10) in Recent and Old Cutaneous Scars is a Potential Mimicker of Desmoplastic Malignant Melanoma.
|
30672775 |
2020 |
|
Skin Nodular Basal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART-1, with high Ki-67 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan-cytokeratin and Ber-EP4).
|
31361351 |
2020 |
|
Basal cell carcinoma, nodular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART-1, with high Ki-67 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan-cytokeratin and Ber-EP4).
|
31361351 |
2020 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Consistently, MLT+Ptero cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP), activated sex-determining region Y-Box10 (SOX10), and also attenuated the expression of Bcl-xL, neural precursor cell expressed developmentally downregulated protein 9 (NEDD9), and SOX9 in CRCs.
|
31671847 |
2019 |
|
Neurofibromatosis 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Epithelioid malignant peripheral nerve sheath tumors (EMPNST) are characterized by diffuse S-100 and SOX10 positivity, frequent immunohistochemical loss of SMARCB1 expression (70%), and rare association with neurofibromatosis type 1.
|
30864974 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We report SOX10 positive cells detected in granulomatous dermatoses and benign lymph nodes.
|
30957251 |
2019 |
|
Skin Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings are comparable to reported in previous studies, and show SOX10 can be a useful adjunct in the differential diagnosis of nodular basaloid skin tumors.
|
30531326 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Mechanistically, we found that αCD147 treatment increased the number of proliferating NG2(+)/PDGFRα(+) oligodendrocyte precursor cells (OPCs) and newly generated mature APC(+)/Sox10(+) oligodendrocytes after stroke, possibly through upregulation of SDF-1/CXCR4 axis in OPCs.
|
31356925 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
When comparing TNBC and TTF1-positive or negative LA, SOX10 had the best sensitivity (62.3%) and specificity (100%) as a marker in favor of TNBC compared with LA, irrespective of TTF1 status (P<0.0001).
|
30628926 |
2019 |
|
Carcinoma breast stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although GATA3 is a more sensitive lineage marker than SOX10 in MBC, SOX10 is a useful adjunct because it is positive in most GATA3-negative breast metastases.
|
30468800 |
2019 |
|
Adenoid cystic carcinoma of salivary gland
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX10 Is a Sensitive Marker for Breast and Salivary Gland Adenoid Cystic Carcinoma: Immunohistochemical Characterization of Adenoid Cystic Carcinomas.
|
31105427 |
2019 |
|
Neuronal intestinal dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sox10 promoter methylation in the peripheral blood was negatively correlated with Sox10 expression in the colon, which was low in control, moderate in HD, and high in IND specimens (r = -0.89).
|
31789936 |
2019 |
|
Eccrine epithelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX10 staining was seen in the majority of sweat gland tumors with the exception of syringoma and microcystic adnexal carcinoma.
|
30531326 |
2019 |
|
Secondary malignant neoplasm of female breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although GATA3 is a more sensitive lineage marker than SOX10 in MBC, SOX10 is a useful adjunct because it is positive in most GATA3-negative breast metastases.
|
30468800 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sections from 6 patients with UM, who had undergone primary enucleation 1978-1995 and 6 paired liver metastases were stained immunohistochemically (SOX10, Melan-A, IDO, TIGIT, and CD8).
|
30993893 |
2019 |
|
Ductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX10 expression in mammary invasive ductal carcinomas and benign breast tissue.
|
30903273 |
2019 |
|
Desmoplastic
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX-10 positivity of non-melanocytes in re-excision specimen could complicate the evaluation of invasive melanoma with an invasive desmoplastic component.
|
30950082 |
2019 |
|
Invasive Cutaneous Melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX-10 positivity of non-melanocytes in re-excision specimen could complicate the evaluation of invasive melanoma with an invasive desmoplastic component.
|
30950082 |
2019 |
|
Azoospermia, Nonobstructive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five genetic variants showed positive correlations with NOA: MTRR c.537T>C (rs161870), odds ratios (OR), 3.686, 95% confidence interval (CI), 1.228-11.066; MTRR, c.1049A>G (rs162036), OR, 3.686, 95% CI, 1.228-11.066; PIWIL1, c.1580G>A (rs1106042), OR, 4.737, 95% CI, 1.314-17.072; TAF4B, c.1815T>C (rs1677016), OR, 3.599, 95% CI, 1.255-10.327; and SOX10 c.927T>C (rs139884), OR, 3.192, 95% CI, 1.220-8.353.
|
31377750 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that overexpression of the transcription factor SOX10 is sufficient to generate surface antigen O4-positive (O4<sup>+</sup>) and myelin basic protein-positive OLs from hPSCs in only 22 days, including from patients with multiple sclerosis or amyotrophic lateral sclerosis.
|
29337119 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of HMB45, MelanA and SOX10 is evident but exceedingly rare in NSCLC cases.
|
30205833 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
All HMSC cases were SOX10 positive, whereas the overlying atypical squamous epithelium and the SCC were SOX10 negative.
|
30071233 |
2018 |
|
Heartburn
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Using fluorescence spectroscopy and data from two long-term (24+ years at completion of this study) whole watershed acidification experiments, that is, the Bear Brook Watershed in Maine (BBWM) and Fernow Experimental Forest in West Virginia (FEF) allowed us to control for factors other than the acidity-change mechanism (e.g., differing vegetation, shifting climate), resulting in the first study we are aware of where the acidity change mechanism could be experimentally isolated at the whole ecosystem and decadal scales as the driver of shifts in DOM dynamics.
|
29430920 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, our results demonstrate that CMTM7 as a tumor suppressor is down-regulated in gastric cancer, and SOX10 can regulate the proliferation and tumor formation of gastric cancer by regulating the expression of CMTM7.
|
30392914 |
2018 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, interventions that reduce HDAC5/SOX10 expression may represent promising avenues in the treatment of neuropathic pain.
|
29447134 |
2018 |