Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an autoimmune blistering disease associated with autoantibodies against BP180 and/or BP230 antigens.
|
31603994 |
2020 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Instead, circulating autoantibodies directed to both collagen XVII, also named BP180, and BP230, are hallmarks of the autoimmune blistering disease bullous pemphigoid (BP).
|
31709656 |
2020 |
Bullous pemphigoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine the diagnostic performance of anti-BP180 IgG and anti-BP230 IgG in BP, to correlate disease activity with autoantibody levels through follow-ups, and to relate BP comorbidities with disease activity and autoantibody levels.
|
31175713 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes.
|
31191560 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgG and IgE autoantibodies against the hemidesmosomal antigens Bullous Pemphigoid (BP) 180 and BP230 are of pathogenic relevance, since autoantibody-antigen binding results in complement activation, immune cells infiltration, impaired hemidesmosomal function, and loss of dermal-epidermal adhesion.
|
30769277 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are several lines of evidence indicating that the physiopathological bases of bullous pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are hallmarked by the production of autoantibodies directed against the hemidesmosomal anchoring proteins BP180 and BP230.
|
31312206 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is the most prevalent autoimmune skin blistering disease and is characterized by the generation of autoantibodies against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230.
|
31824475 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sixty seven percent of BP230-type BP cases show a mild clinical phenotype.
|
30394605 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
BP180 NC16A, BP230, and full-length BP180 ELISAs were used to detect the BP-IgG autoantibodies.
|
31297116 |
2019 |
Bullous pemphigoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These patients' demographic characteristics and BP180 and BP230 levels were compared with those of a BP control group who were positive for BP180 or BP230 autoantibodies and had positive DIF study findings.
|
30928465 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that a portion of the active BP model mice show intermolecular epitope spreading from human COL17 to murine BP230.
|
31275329 |
2019 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by autoantibody production against BP180 and BP230.
|
29423547 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in recent years have further elucidated the role of eosinophils and IgE autoantibodies.
|
30042946 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have found an association between BP, ND and specific serologic profile characterized by higher levels of anti-BP180 and anti-BP230 (t(45)=2.319, p=0.025 and t(45)= 2.486, p=0.017, respectively), as compared to BP patients without ND.
|
30062977 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs).
|
29619029 |
2018 |
Bullous pemphigoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mucous membrane pemphigoids (MMPs) and bullous pemphigoid (BP) are autoimmune bullous diseases that share physiopathological features: both can result from autoantibodies directed against BP180 or BP230 antigens.
|
29881377 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mucosal Involvement in Bullous Pemphigoid Is Mostly Associated with Disease Severity and to Absence of Anti-BP230 Autoantibody.
|
29662486 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP180 or BP230 are produced.
|
29411416 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230.
|
29607480 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an autoimmune and inflammatory skin disease associated with subepidermal blistering and autoantibodies directed against the hemidesmosomal components BP180 and BP230.
|
29545809 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria.
|
29686678 |
2018 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collagen XVII and dystonin-e have been identified as target antigens.BP affects mostly the elderly.
|
28286109 |
2017 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is the most common autoimmune blistering disease and is linked to IgG recognition of 2 hemidesmosomal antigens, that is, BP230 (BP antigen 1) and BP180 (BP antigen 2, collagen XVII).
|
28101965 |
2017 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder characterized by circulating serum IgG antibodies against two hemidesmosomal proteins: BP180 and BP230.
|
27709645 |
2017 |
Bullous pemphigoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients.
|
28833620 |
2017 |