|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Varying levels of PH-20 in mammary tissue may contribute to early invasion and metastasis of breast cancer.
|
11922735 |
2002 |
|
Malignant neoplasm of urinary bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
At IC50 for HAase activity inhibition (5-20 μg/ml [0.4-1.7 μM]), sHA-F significantly inhibited proliferation, motility and invasion of HYAL-1 expressing BCa cells (253J-Lung, HT1376, UMUC-3), P<0.001. sHA-F did not affect the growth of HYAL-1 non-expressing BCa (5637, RT4, T24, TCCSUP) and normal urothelial (Urotsa, SV-HUC1) cells. sHA-F treatment induced apoptosis by death receptor pathway. sHA-F downregulated transcript and/or protein levels of HA receptors (CD44, RHAMM), p-AKT, β-catenin, pβ-Catenin(S552), Snail and Twist but increased levels of pβ-Catenin(T41/S45), pGSK-3α/β(S21/S9) and E-cadherin. sHA-F also inhibited CD44/Phosphoinositide 3-kinase (PI-3K) complex formation and PI-3K activity.
|
27419371 |
2017 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
At IC50 for HAase activity inhibition (5-20 μg/ml [0.4-1.7 μM]), sHA-F significantly inhibited proliferation, motility and invasion of HYAL-1 expressing BCa cells (253J-Lung, HT1376, UMUC-3), P<0.001. sHA-F did not affect the growth of HYAL-1 non-expressing BCa (5637, RT4, T24, TCCSUP) and normal urothelial (Urotsa, SV-HUC1) cells. sHA-F treatment induced apoptosis by death receptor pathway. sHA-F downregulated transcript and/or protein levels of HA receptors (CD44, RHAMM), p-AKT, β-catenin, pβ-Catenin(S552), Snail and Twist but increased levels of pβ-Catenin(T41/S45), pGSK-3α/β(S21/S9) and E-cadherin. sHA-F also inhibited CD44/Phosphoinositide 3-kinase (PI-3K) complex formation and PI-3K activity.
|
27419371 |
2017 |
|
Carcinoma of bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
At IC50 for HAase activity inhibition (5-20 μg/ml [0.4-1.7 μM]), sHA-F significantly inhibited proliferation, motility and invasion of HYAL-1 expressing BCa cells (253J-Lung, HT1376, UMUC-3), P<0.001. sHA-F did not affect the growth of HYAL-1 non-expressing BCa (5637, RT4, T24, TCCSUP) and normal urothelial (Urotsa, SV-HUC1) cells. sHA-F treatment induced apoptosis by death receptor pathway. sHA-F downregulated transcript and/or protein levels of HA receptors (CD44, RHAMM), p-AKT, β-catenin, pβ-Catenin(S552), Snail and Twist but increased levels of pβ-Catenin(T41/S45), pGSK-3α/β(S21/S9) and E-cadherin. sHA-F also inhibited CD44/Phosphoinositide 3-kinase (PI-3K) complex formation and PI-3K activity.
|
27419371 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
Among the HA family members, transcript levels of the HA synthases, HYAL-1, CD44v, and RHAMM were 4- to 16-fold higher in BCa tissues than in normal tissues (P < .0001); however, CD44s levels were lower.
|
20960509 |
2011 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Among the HA family members, transcript levels of the HA synthases, HYAL-1, CD44v, and RHAMM were 4- to 16-fold higher in BCa tissues than in normal tissues (P < .0001); however, CD44s levels were lower.
|
20960509 |
2011 |
|
Carcinoma of bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
Among the HA family members, transcript levels of the HA synthases, HYAL-1, CD44v, and RHAMM were 4- to 16-fold higher in BCa tissues than in normal tissues (P < .0001); however, CD44s levels were lower.
|
20960509 |
2011 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two cell lines were engineered to overexpress hyal-1: a breast cancer line (CAL51) and a prostate cancer line (PC3M).
|
11802201 |
2002 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
PH-20 was present in 12/12 (100%) normal breast tissues; 8/12 (66.7%) DCIS; 13/13 (100%) invasive breast cancers; and 8/14 (57.1%) metastases.
|
11922735 |
2002 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two cell lines were engineered to overexpress hyal-1: a breast cancer line (CAL51) and a prostate cancer line (PC3M).
|
11802201 |
2002 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Varying levels of PH-20 in mammary tissue may contribute to early invasion and metastasis of breast cancer.
|
11922735 |
2002 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL-1 expression in laryngeal squamous cell carcinomas is elevated compared to normal tissues of same patients.
|
31207115 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL-1 enzymatic activity at stable state was inversely correlated with FEV<sub>1</sub> % pred (p=0.034) and survival time (p=0.017).Serum HA is associated with COPD severity and predicts overall survival.
|
30705130 |
2019 |
|
Thromboangiitis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both PH20 and HMW-HA upregulated CD44 expression and inhibited SMAD2/3 expression in the TAO group, and the inhibitory effects were partially reversed by CD44 blockage.
|
30947333 |
2019 |
|
Thyroid associated opthalmopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study aimed to explore the effects of PH20 (a hyaluronidase) and HA on TGFβ1-induced differentiation in pOFs cultured from thyroid-associated ophthalmopathy (TAO) and control subjects.
|
30947333 |
2019 |
|
Subfertility, Male
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defect.
|
31670981 |
2019 |
|
Nasal Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
On mRNA level, it was found that hyal-1-wt was decreased in NPs compared to NM and hyal-1-v3, -v4 and -v5 were substantially increased.
|
26661071 |
2016 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although HYAL-1 is a critical determinant of tumor progression and a marker for cancer diagnosis and metastasis prediction, it has not been evaluated as a target for cancer therapy.
|
21555367 |
2011 |
|
Epithelial ovarian cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL-1 enzyme activity was measured in EOC cell lines and in plasma samples from patients.
|
21695196 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL-1 enzyme activity was measured in EOC cell lines and in plasma samples from patients.
|
21695196 |
2011 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intratumoral treatment of human melanoma xenografts with AdwtRGD-PH20 resulted in degradation of hyaluronan (HA), enhanced viral distribution, and induced tumor regression in all treated tumors.
|
20442708 |
2010 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This is the first study to demonstrate the cellular localization of HA and its synthases and that Hyal 3 mRNA is predominant in endometrial cancer.
|
15936804 |
2005 |
|
Mucopolysaccharidoses
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we surveyed a variety of patients with phenotypes similar to those observed in MPS, but without significant mucopolysacchariduria to determine if some are based on aberrations in serum hyaluronidase (Hyal-1) activity.
|
16311883 |
2005 |
|
Mucopolysaccharidosis IV
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
|
16311883 |
2005 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Real-time RT-PCR was used to determine the mRNA expression of Hyal 1, Hyal 2 (n = 13) and Hyal 3 (n = 11) in endometrial carcinomas.
|
15936804 |
2005 |