Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 AlteredExpression disease BEFREE Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer. 31139014 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE Furthermore, FN1, TIMP1, MMP2, and SPARC are correlated with SERPINE1 and may serve as therapeutic targets in reversing EMT in GC. 31218131 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 AlteredExpression disease BEFREE Immunohistochemical analysis of SPARC expression was performed in 117 surgically resected GC specimens, and the localization of SPARC positive cells, as well as the rassociation between SPARC expression and clinicopathological characteristics were evaluated. 29403557 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 GeneticVariation disease BEFREE SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility. 28962925 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE The investigations of SERPINE1 and SPARC may promote their predictive and prognostic value in GC. 30410354 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 AlteredExpression disease BEFREE Western blotting and immunofluorescence staining were applied for verifying the endogenous expression of SPARC in human cell lines of gastric cancer and fibroblast. 29156791 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression. 24676680 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE Overexpression of the SPARC gene may be a useful independent predictor of outcomes in patients with gastric cancer. 24018911 2013
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 GeneticVariation disease BEFREE An individual coding polymorphism and the haplotype of the SPARC gene predict gastric cancer recurrence. 22491017 2013
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE Thus, targeting of SPARC could be an effective therapeutic approach against gastric cancer. 20525171 2010
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease BEFREE These data indicate the potential of SPARC as a prognostic marker for gastric cancer. 15558074 2004
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker disease RGD Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. 12359048 2002
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 AlteredExpression disease BEFREE The present results suggest that osteonectin is highly expressed in reactive stroma associated with invasive differentiated adenocarcinomas and that it may serve as a useful clinical diagnostic marker for stomach cancer. 12104055 2002