Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE These findings define a novel and functionally important role of SPARC in OvCa and not only bridge the knowledge gap but highlight the need to consider SPARC protein expression in therapeutic development. 30765860 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE We used a syngeneic model of OvCa in <i>Sparc</i>-deficient and proficient mice to gain comprehensive insight into the paracrine effect of stromal-SPARC in metabolic programming of OvCa in the peritoneal milieu. 30332737 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE These results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D. 29075785 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 AlteredExpression disease BEFREE High SPARC expression was associated with high stage, low differentiation, lymph node metastasis and poor prognosis of ovarian cancer. 22879971 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease CTD_human Investigation of primary tumors revealed that the Sparc promoter is methylated in 68% of primary ovarian tumors and that the levels of SPARC protein decrease as the disease progresses from low to high grade. 19177197 2009
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 PosttranslationalModification disease BEFREE Aberrant promoter methylation of SPARC in ovarian cancer. 19177197 2009
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 AlteredExpression disease LHGDN These results indicate, for the first time, that the effects of tumor SPARC as a negative regulator of ovarian cancer are mediated through decreased recruitment of macrophages and downregulation of the associated inflammation. 18813349 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE SPARC ameliorates ovarian cancer-associated inflammation. 18813349 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 AlteredExpression disease BEFREE The immunohistochemical data presented here confirmed the importance of diminished SPARC expression in ovarian cancer development. 11485919 2001
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 AlteredExpression disease BEFREE SPARC has been reported to be markedly down-regulated in ovarian carcinomas relative to the normal surface epithelium and has been suggested to act as a tumor suppressor in ovarian cancer. 10502421 1999