Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 Biomarker disease BEFREE These findings define a novel and functionally important role of SPARC in OvCa and not only bridge the knowledge gap but highlight the need to consider SPARC protein expression in therapeutic development. 30765860 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 Biomarker disease BEFREE We used a syngeneic model of OvCa in <i>Sparc</i>-deficient and proficient mice to gain comprehensive insight into the paracrine effect of stromal-SPARC in metabolic programming of OvCa in the peritoneal milieu. 30332737 2018
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 Biomarker disease BEFREE These results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D. 29075785 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 AlteredExpression disease BEFREE High SPARC expression was associated with high stage, low differentiation, lymph node metastasis and poor prognosis of ovarian cancer. 22879971 2012
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 Biomarker disease CTD_human Addition of exogenous SPARC, as well as ectopic expression by an adenoviral vector, resulted in decreased proliferation of ovarian cancer cell lines. 19177197 2009
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 PosttranslationalModification disease BEFREE Aberrant promoter methylation of SPARC in ovarian cancer. 19177197 2009
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 Biomarker disease BEFREE SPARC ameliorates ovarian cancer-associated inflammation. 18813349 2008
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 AlteredExpression disease BEFREE The immunohistochemical data presented here confirmed the importance of diminished SPARC expression in ovarian cancer development. 11485919 2001
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.380 AlteredExpression disease BEFREE SPARC mRNA and protein expression was examined in 24 human invasive ovarian cancers, 5 tumors of low malignant potential (LMP), and 8 nonmalignant ovaries by in situ hybridization and immunohistochemistry. 10502421 1999