|
caruncle
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to document the expression and functional role of BMPs in the placental (caruncle; CAR, cotyledon; COT) during different stages of pregnancy in water buffalo.
|
31445010 |
2020 |
|
Renal cancer metastatic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CAIX-specific CAR-T Cells and Sunitinib Show Synergistic Effects Against Metastatic Renal Cancer Models.
|
31574023 |
2020 |
|
Adenoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Eight- to fifteen-year-old dogs with carcinoma (CAR Group; N=5), epithelioma (EPI Group; N=16) or adenoma (ADE Group; N=24) were used.
|
31028190 |
2019 |
|
Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Neutropenia, thrombocytopenia, and anemia occur frequently (94, 80, and 51%, respectively) after CAR-T cell infusion, and are associated with a biphasic nature, as in 93% of patients hematologic toxicity occurs after 21 days from cell infusion.
|
30809033 |
2019 |
|
Blood Coagulation Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Improving the safety of CAR-T cell therapy by controlling CRS-related coagulopathy.
|
31055613 |
2019 |
|
Bone neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In this review, we briefly describe the CAR-T approach and discuss its applications in primary bone tumors.
|
31441962 |
2019 |
|
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the cytolytic and mechanistic activity of anti-CD19 chimeric antigen receptor natural killer (CD19.CAR.NK92) therapy in lymphoma cell lines (diffuse large B-cell, follicular, and Burkitt lymphoma), including rituximab- and obinutuzumab-resistant cells, patient-derived cells, and a human xenograft model.
|
31772298 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These studies support the initiation of a phase I study to evaluate the safety and potential efficacy of micromolar affinity tuned CAR T cells against newly diagnosed anaplastic and refractory or recurrent thyroid cancers.
|
31337787 |
2019 |
|
Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Weekly subcutaneous injections of PGN-NP attenuated skin fibrosis in BLM-induced scleroderma model mice.
|
30655107 |
2019 |
|
Gingival Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Lipid A of ΔPGN_1123 mutants is penta-acylated and devoid of tetra-acylated structures, and the mutant strain provokes a strong TLR4-mediated proinflammatory response, in contrast to the negligible response elicited by wild-type <i>P. gingivalis</i> Heterologous expression of PGN_1123 in <i>Bacteroides thetaiotaomicron</i> promoted lipid A deacylation, confirming that PGN_1123 encodes the lipid A deacylase enzyme.<b>IMPORTANCE</b> Periodontitis, commonly referred to as gum disease, is a chronic inflammatory condition that affects a large proportion of the population.
|
30782639 |
2019 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This review focuses on application of CAR-T cells in hematologic malignancies beyond targeting CD19, with specific attention to Hodgkin's lymphoma and acute myeloid leukemia.
|
30632631 |
2019 |
|
Immune System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets.
|
31186046 |
2019 |
|
Leukemia, Mast-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a case of a refractory MCL in a patient who had relapsed after conventional chemotherapy and autologous CAR T cell therapy.
|
30791947 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014.
|
30502305 |
2019 |
|
Lymphohistiocytosis, Hemophagocytic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The overwhelming release of cytokines and chemokines by activated CAR-T and other secondarily activated immune effector cells can lead to cytokine release syndrome (CRS), which can have clinical and pathophysiology similarities to systemic inflammatory response syndrome and macrophage activating syndrome/hemophagocytic lymphohistiocytosis.
|
31355491 |
2019 |
|
Lymphoma, Follicular
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant differences in CAR-T cell in vivo expansion/persistence were observed between FL and tFL patients.
|
31648294 |
2019 |
|
Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore CAR-T therapy in NSCLC and mesothelioma, second-generation CAR-T cells were constructed targeting mesothelin (MSLN), which is abundant in NSCLC and mesothelioma but is under expressed in normal tissues.
|
30651858 |
2019 |
|
Myocarditis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CAR transcription levels were significantly lower (P=0.012) in patients with myocarditis compared with controls, and a significant decrease was observed (P=0.023) in CAR mRNA levels among patients with borderline myocarditis compared with the no myocarditis group.
|
31257515 |
2019 |
|
Delirium, Dementia, Amnestic, Cognitive Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Neuropsychiatric symptoms are common among older people with neurocognitive disorders in CAR and ROC.
|
30255569 |
2019 |
|
Pancytopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Following lymphodepletion, CAR-T cells targeting the tumor-associated antigen ROR1 lysed tumors in mice but induced lethal bone marrow failure due to recognition of ROR1<sup>+</sup> stromal cells.
|
30889382 |
2019 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Lipid A of ΔPGN_1123 mutants is penta-acylated and devoid of tetra-acylated structures, and the mutant strain provokes a strong TLR4-mediated proinflammatory response, in contrast to the negligible response elicited by wild-type <i>P. gingivalis</i> Heterologous expression of PGN_1123 in <i>Bacteroides thetaiotaomicron</i> promoted lipid A deacylation, confirming that PGN_1123 encodes the lipid A deacylase enzyme.<b>IMPORTANCE</b> Periodontitis, commonly referred to as gum disease, is a chronic inflammatory condition that affects a large proportion of the population.
|
30782639 |
2019 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lipid A of ΔPGN_1123 mutants is penta-acylated and devoid of tetra-acylated structures, and the mutant strain provokes a strong TLR4-mediated proinflammatory response, in contrast to the negligible response elicited by wild-type <i>P. gingivalis</i> Heterologous expression of PGN_1123 in <i>Bacteroides thetaiotaomicron</i> promoted lipid A deacylation, confirming that PGN_1123 encodes the lipid A deacylase enzyme.<b>IMPORTANCE</b> Periodontitis, commonly referred to as gum disease, is a chronic inflammatory condition that affects a large proportion of the population.
|
30782639 |
2019 |
|
Pleural effusion disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Comparing NSCLC PE and published plasma levels of CAR-T recipients, both were dominated by sIL-6Rα and IL-6 but NSCLC PE had more VEGF, FGF2 and TNFα, and less IL-2, IL-4, IL-13, IL-15, MIP1α and IFNγ.
|
31741710 |
2019 |
|
Systemic Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Weekly subcutaneous injections of PGN-NP attenuated skin fibrosis in BLM-induced scleroderma model mice.
|
30655107 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy.
|
31337787 |
2019 |