|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study offers a reference for future research regarding the application in solid and hematologic malignancies, side effects and relapse, and even the production processes of CAR T cells.
|
30621018 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This review summarizes difference of CAR T applications in solid and blood cancers.
|
28272967 |
2017 |
|
Hematologic Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CAR-T therapy has shown great success treating blood cancers, but drawbacks include high manufacturing costs and potentially fatal toxicities such as cytokine release syndrome.
|
30075127 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma.
|
31571160 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR-T cell-based immunotherapy has shown great promise in clinical trials for the treatment of hematological malignancies.
|
31814915 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite the great success of chimeric antigen receptor T (CAR-T)-cell therapy in the treatment of hematologic malignancies, CAR-T-cell therapy is limited in solid tumors, including hepatocellular carcinoma (HCC).
|
31484657 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chimeric antigen receptor-modified (CAR-modified) T cells have shown promising therapeutic effects for hematological malignancies, yet limited and inconsistent efficacy against solid tumors.
|
29769444 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR-T has shown promise in a number of other hematologic malignancies, and toxicities have become more manageable as its use is becoming more widespread.
|
30715612 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies.
|
31186046 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, the inhospitable solid TME becomes a major hurdle in translating the success of CAR T cell therapy in hematological malignancies to solid tumors.
|
30906625 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR T cells have shown dramatic effects against blood cancers, but they have had little impact on solid tumors.
|
25583818 |
2015 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies.
|
30760795 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR-T cell therapy has achieved gratifying breakthrough in hematological malignancies and promising outcome in solid tumor as showed in various clinical trials.
|
28356156 |
2017 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because CAR-T therapy has shown great success in treating CD19-positive hematological malignancies, its application has been explored in the treatment of solid tumors, such as liver cancer.
|
29861325 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Aim:</b> Chimeric antigen receptor-engineered T (CAR-T) cells have gained huge success in treating hematological malignancies, yet the CD3ζ-based CAR-T therapies have not shown comparable clinical benefits in solid tumors.
|
31268375 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The biggest advances have been made with CAR T cells and many of those studies are now FDA approved as a routine treatment for some hematologic malignancies.
|
31705854 |
2020 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we discuss the structure of the CAR, current clinical advantages from finished and ongoing trials, adverse effects, challenges and controversies, new engineering methods of CAR, and clinical considerations that are associated with CAR T cell therapy both in hematological malignancies and solid tumors.
|
30108584 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas much of the early success with CAR-T cells has been demonstrated with hematological malignancies, important barriers remain for the application of CAR-T cell therapies for the management of metastatic solid tumors.
|
27910858 |
2017 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite its revolutionary success in hematological malignancies, chimeric antigen receptor T (CAR-T) cell therapy faces disappointing clinical results in solid tumors.
|
30734529 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinical success of autologous CD19-directed chimeric antigen receptor T cells (CAR Ts) in acute lymphoblastic leukemia and non-Hodgkin lymphoma suggests that CAR Ts may be a promising therapy for hematological malignancies, including multiple myeloma.
|
31005597 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR-T therapy has achieved encouraging breakthroughs in the treatment of hematological malignancies.
|
30410941 |
2018 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review reports the history of adoptive immunotherapy using CAR-Ts, the CAR-T manufacturing process, and T cell therapies in development for hematological malignancies.
|
27865176 |
2016 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review focuses on application of CAR-T cells in hematologic malignancies beyond targeting CD19, with specific attention to Hodgkin's lymphoma and acute myeloid leukemia.
|
30632631 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma.
|
30659408 |
2019 |
|
Hematologic Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although CAR T cell therapy mediates robust responses in patients with hematological malignancies, this approach has been less effective for treating patients with solid tumors.
|
30842774 |
2019 |