|
Abdomen distended
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
ABLEPHARON-MACROSTOMIA SYNDROME
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We explore the role of the predicted decrease in plasma OPN levels in humans upon high-altitude exposure and its relationship with acute mountain sickness (AMS), as well as superoxide dismutase (SOD) and malondialdehyde (MDA).
|
30165389 |
2018 |
|
Abnormal granulation tissue
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate OPN expression in an equine model of wound healing and in clinical specimens of equine exuberant granulation tissue and human keloids in an effort to better understand the contribution of this protein to inflammation-associated skin fibrosis.
|
25290989 |
2016 |
|
Abnormality of the gastrointestinal tract
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.
|
23354516 |
2013 |
|
Acute alcoholic liver disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: Our study suggests that sCD14, LBP, OPN, sCD163, and sCD206 are biomarkers to indicate severity and predict clinical outcomes in AH.
|
30891779 |
2019 |
|
Acute Chest Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
To our knowledge and beyond the disease context of ACS, this study constitutes the first demonstration of a critical role for OPN in the positive regulation of inflammation through increased IL-17 production by CD4(+) CD45RA(-) FOXP3(lo) cells.
|
22711477 |
2012 |
|
Acute Chest Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that osteopontin might be a biomarker for incident ACS, using osteopontin adds moderately to traditional cardiovascular risk factors.
|
30914768 |
2019 |
|
Acute colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OPN deficiency resulted in an elevated disease activity index, shortened colon length, and aggravated histological signs in mice with DSS-induced acute colitis compared to WT mice.
|
30146676 |
2019 |
|
Acute Coronary Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells.
|
22711477 |
2012 |
|
Acute Coronary Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
|
31530226 |
2019 |
|
Acute Coronary Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity.
|
30914768 |
2019 |
|
Acute encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The CSF:serum ratios of OPN, CC chemokine ligand (CCL)4, and interleukin (IL)-10 were significantly higher in AE than in FC.
|
31787380 |
2020 |
|
Acute heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF.
|
30547895 |
2019 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
|
20623750 |
2011 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat.
|
11274264 |
2001 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
|
20623750 |
2011 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat.
|
11274264 |
2001 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggest that ALL interacts with extracellular OPN within the malignant BM, and that this interaction induces cell cycle exit in leukemic blasts, protecting them from cytotoxic chemotherapy.
|
23589674 |
2013 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis.
|
28326824 |
2017 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Finally, we constructed a gene expression- and interaction-based outcome predictor consisting of 27 genes (including GRB2, GAB1, GLI1, IRS1, RUNX2, and SPP1), which correlated with overall survival in BCR-ABL-positive adult ALL (P = .0001), independent of age (P = .25) and WBC count at presentation (P = .003).
|
17312329 |
2007 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the frequency of MetS in survivors of acute lymphoblastic leukemia (ALL) and to establish the relationship between serum OPN levels and anthropometric measurements and glucose metabolism.
|
29641359 |
2018 |
|
Acute monocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immunocytochemistry of bone marrow biopsies of AML patients confirmed the positive expression of osteopontin in blasts near the para-trabecular bone marrow, whereas osteopontin was rarely detected in mononuclear cell isolates.
|
29340063 |
2017 |
|
Acute monocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The OPN gene polymorphism confers the susceptibility and response to Ara-C based chemotherapy in Chinese AML patients.
|
25591760 |
2015 |