|
Hyperparathyroidism, Secondary
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of oral treatment with paricalcitol, a potent vitamin D receptor activator, on arterial stiffness and osteopontin, a marker of atherosclerosis, in hypertensive patients with chronic kidney disease (CKD) and secondary hyperparathyroidism.
|
29305902 |
2020 |
|
Enthesopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy?
|
31843680 |
2020 |
|
Dissection of proximal aorta
|
0.010 |
Biomarker
|
disease |
BEFREE |
ROC analysis showed that OPN could be indicators for TAAD diagnosis with sensitivity of 0.92 and specificity of 0.99.
|
31786503 |
2020 |
|
Chronic graft-versus-host disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis focused on previously identified cGVHD cellular biomarkers, including naive helper T (Th) cells, recent thymic emigrant (RTE) Th cells, CD21<sup>low</sup> B cells, CD56<sup>bright</sup> NK<sub>reg</sub> cells, and T<sub>reg</sub> cells ST2, osteopontin, sBAFF, sCD25, TIM-3, matrix metallopeptidase 3, ICAM-1, CXCL10, and soluble aminopeptidase N. The ATG-treated group had a >10-fold decrease in both RTE naive Th and naive Th cells (P < .0001) and a 10-fold increase in CD56<sup>bright</sup> NK<sub>reg</sub> cells (P < .0001).
|
31756535 |
2020 |
|
Acute encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The CSF:serum ratios of OPN, CC chemokine ligand (CCL)4, and interleukin (IL)-10 were significantly higher in AE than in FC.
|
31787380 |
2020 |
|
Nonrheumatic aortic (valve) stenosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study compared smooth muscle α-actin (α-SMA), osteopontin (OPN), and suppression of tumorigenicity 2 (ST2) expression between specimens from fibrotic and calcific stages of NR-AS and observed the effects and mechanisms of phenotypic transition of porcine valvular interstitial cells (VICs) in the presence of IL-33.
|
31416779 |
2020 |
|
Acute alcoholic liver disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: Our study suggests that sCD14, LBP, OPN, sCD163, and sCD206 are biomarkers to indicate severity and predict clinical outcomes in AH.
|
30891779 |
2019 |
|
Congenital arteriovenous malformation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation.
|
31275742 |
2019 |
|
Bone neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A subpopulation of osteoblasts was identified in the bone tumor microenvironment in vivo of both humans and mice with bone metastatic breast cancer that express RUNX2/OCN/OPN but is negative for IL-6 and alpha-smooth muscle actin.
|
30813947 |
2019 |
|
Eisenmenger Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results showed that OPN was increased in lungs and plasma of patients with Eisenmenger syndrome; moreover, OPN and α<sub>V</sub>β<sub>3</sub>-integrin expression levels were augmented in rat lungs exposed to systemic-to-pulmonary shunt.
|
30893567 |
2019 |
|
Giant Cell Epulis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this retrospective study, the presence of matrix metalloproteinases-2 and osteopontin in 37 cases of central giant cell granuloma and 37 cases of peripheral giant cell granuloma paraffin blocks were assessed by streptavidin-biotin immunohistochemistry.
|
29339027 |
2019 |
|
Angle Closure Glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We assume that elevated levels of OPN and cystatin C in POAG and PACG along with altered cathepsin levels may contribute to ECM aberration in glaucoma.
|
30994369 |
2019 |
|
Primary angle-closure glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We assume that elevated levels of OPN and cystatin C in POAG and PACG along with altered cathepsin levels may contribute to ECM aberration in glaucoma.
|
30994369 |
2019 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum osteopontin level is associated with heart valve calcification in HD patients, but there was no relationship found with FGF-23.
|
30369401 |
2019 |
|
Huntington Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum osteopontin level is associated with heart valve calcification in HD patients, but there was no relationship found with FGF-23.
|
30369401 |
2019 |
|
Leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
OPN, further evaluated as a target for Leishmaniasis control represents an additional interest in improving vaccination strategies against the parasites.
|
30736736 |
2019 |
|
Lipoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of OPN and CA9 was exclusively upregulated in the ASCs of LP.
|
31640774 |
2019 |
|
Osteitis Deformans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with PDB presented higher levels of osteopontin and RANKL.
|
31384515 |
2019 |
|
Pemphigus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The growth observed in OPN levels in pemphigus patients suggests the role of OPN in pemphigus pathogenesis, but there is a need for more extensive studies to show how OPN can be associated with the PV pathogenesis and whether OPN could be used as an important therapeutic target in pemphigus disease.
|
31136685 |
2019 |
|
Pemphigus Vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of OPN in PV has not been well studied so far.
|
31136685 |
2019 |
|
Pneumococcal Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aimed to investigate whether OPN affects inflammation and vulnerability to pneumococcal infection in atopic asthma.
|
30362569 |
2019 |
|
Congenital heart disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Recent studies indicated that osteopontin (OPN) was involved in the genesis and progression of pulmonary arterial hypertension (PAH); however, its role in congenital heart disease-associated PAH (CHD/PAH) remains unknown.
|
30893567 |
2019 |
|
Allergic asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both allergen challenge in individuals with allergic asthma and the intranasal instillation of HDM in mice resulted in increased OPN levels in bronchoalveolar lavage fluid (BALF).
|
30362569 |
2019 |
|
Granuloma, Giant Cell Reparative
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this retrospective study, the presence of matrix metalloproteinases-2 and osteopontin in 37 cases of central giant cell granuloma and 37 cases of peripheral giant cell granuloma paraffin blocks were assessed by streptavidin-biotin immunohistochemistry.
|
29339027 |
2019 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therapeutic effect of combined hyperbaric oxygen and radiation therapy for single brain metastasis and its influence on osteopontin and MMP-9.
|
30651823 |
2019 |