SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones. 28442375 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE We suggest that such genetic findings may help to clarify the function of OPN in nephrolithiasis. 17519954 2007
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins. 29054323 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 GeneticVariation disease BEFREE These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis. 21044748 2010
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet. 27784695 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models. 31690714 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity. 22466558 2012
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis. 30623435 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria. 29353465 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial. 11703581 2001
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo. 30720053 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis. 30114399 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones. 30016645 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Based on these data, it is proposed that during urolithiasis, secretion of osteopontin (uropontin) and osteocalcin (or osteocalcin-related gene/protein), and the subsequent incorporation of these proteins into kidney stone matrix, may influence the nucleation, growth processes, aggregation, and/or tubular adhesion of renal calculi in mammalian kidneys. 8619372 1995
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses. 27297950 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression. 27717860 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 GeneticVariation disease BEFREE SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis. 23235966 2012
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones. 19581305 2009
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation. 30569197 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease CTD_human Structure and expression of the mRNA encoding urinary stone protein (osteopontin). 8325891 1993
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease CTD_human Phosphate is a specific signal for induction of osteopontin gene expression. 10890885 2000
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease LHGDN Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. 15954903 2005
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease RGD Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats. 21378157 2011