|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
|
31690714 |
2019 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity.
|
22466558 |
2012 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.
|
30623435 |
2019 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria.
|
29353465 |
2018 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial.
|
11703581 |
2001 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.
|
30720053 |
2019 |
|
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis.
|
30114399 |
2018 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones.
|
30016645 |
2018 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these data, it is proposed that during urolithiasis, secretion of osteopontin (uropontin) and osteocalcin (or osteocalcin-related gene/protein), and the subsequent incorporation of these proteins into kidney stone matrix, may influence the nucleation, growth processes, aggregation, and/or tubular adhesion of renal calculi in mammalian kidneys.
|
8619372 |
1995 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses.
|
27297950 |
2017 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression.
|
27717860 |
2017 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
CTD_human |
Phosphate is a specific signal for induction of osteopontin gene expression.
|
10890885 |
2000 |
|
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.
|
23235966 |
2012 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones.
|
19581305 |
2009 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation.
|
30569197 |
2019 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
RGD |
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
|
21378157 |
2011 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
RGD |
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
|
16651633 |
2006 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
CTD_human |
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
|
16651633 |
2006 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas.
|
9615723 |
1998 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis.
|
28326824 |
2017 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process.
|
30140373 |
2018 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy.
|
23891093 |
2013 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Our findings show re-activation of the embryonic-type transcriptional regulation of SPP1 in malignant gliomas and point to the importance of SPP1-CD44 interactions in self-renewal and pluripotency glioma initiating cells.
|
28030801 |
2017 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Five potential markers (CD44 antigen (CD44), growth arrest and DNA-damage-inducible, alpha (GADD45A), fibronectin 1 (FN1), CD63 antigen (CD63) and secreted phosphoprotein 1 (SPP1)) showed expression patterns that correlated significantly with malignant glioma.
|
20150644 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Glomerular expression of osteopontin in biopsies of human crescentic glomerulonephritis (N = 25), IgA nephropathy with crescents (N = 2), and diffuse proliferative lupus glomerulonephropathy with crescents (N = 1) was studied by immunohistochemistry, in situ hybridization, and combined immunohistochemistry/in situ hybridization.
|
10620192 |
2000 |