SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease LHGDN These data suggest that OPN genotypes may influence MS development and progression due to their influence on OPN levels. 15885319 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease LHGDN Osteopontin thus appears to regulate T helper cell-1 (TH1)-mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS. 11721059 2001
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE To evaluate the relationship between CSF NF-L and OPN levels and brain grey and white matter volumes in patients with clinically isolated syndrome (CIS) suggestive of MS. 28537100 2018