SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.340 AlteredExpression group BEFREE Elevation of osteopontin levels in brain tumor cells reduces burden and promotes survival through the inhibition of cell dispersal. 17928956 2008
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.340 Biomarker group CTD_human Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.340 Biomarker group BEFREE Its engagement by osteopontin physiologically induces macrophage chemotaxis, a mechanism that may be utilized by metastatic brain tumors in the process of dissemination. 11136998 2000
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.340 AlteredExpression group BEFREE Using a number of different brain tumor-derived cell lines we have demonstrated that the mRNA for osteopontin (OPN), which is substantially over-expressed by some tumors in comparison with normal tissues, is preferentially expressed in high grade and metastatic brain tumors compared to low grade brain tumors. 9615723 1998
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.340 AlteredExpression group BEFREE This study demonstrates the expression of OPN in human glioma representative of brain tumors. 7837791 1995