|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
OPN production has been associated with several pathological conditions, including autoimmune diseases (e.g. lupus, multiple sclerosis and rheumatoid arthritis) and cancer.
|
31126876 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
OPN TT genotype and T allele were significantly detected in SLE patients more than controls (P = 0.003, P < 0.001 respectively).
|
30898714 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Serum OPN levels were higher in the LN patients than in HC and in SLE patients without renal involvement (p<0.0001 and 0.0032, respectively), regardless of the phase of renal activity.
|
31074728 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in SLE patients increased circulating levels of OPN were associated with the use of hydroxychloroquine and the positivity for the anti-dsDNA autoantibodies.
|
30767212 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001).
|
30647177 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conclusions Our meta-analysis revealed a significantly higher circulating OPN level in SLE patients, a trend of positive correlation between OPN levels and SLE activity, and a significant association between OPN 1239 C/A and 9250 C/T polymorphisms, and SLE development.
|
27307447 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Serum osteopontin levels were higher in the SSc and SLE groups compared to the HC group (p < 0.01 and p < 0.001, respectively).
|
29264880 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
We further detected five distinct inflammatory and metabolic pathways such as TWEAK, osteopontin, endochondral ossification, fluropyrimidine activity and urea cycle and metabolism of amino groups that significantly contribute to the pathogenesis of lupus (P < 0.05).
|
26403095 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
A better understanding of the role of OPN in SLE will contribute to more precise diagnosis and treatment of the disease.
|
24917428 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data on rs7574865 in the STAT4 gene and rs9138 in SPP1 were replicated for associations with SLE when comparing cases and controls (corrected P values ranging from 0.0043 to 0.027).
|
24023622 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Data on rs7574865 in the STAT4 gene and rs9138 in SPP1 were replicated for associations with SLE when comparing cases and controls (corrected P values ranging from 0.0043 to 0.027).
|
24023622 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In humans, typing of the +1239A/C single nucleotide polymorphism (SNP) in the 3UTR of the Opn gene (SPP1) showed that +1239C carriers displayed higher Opn serum levels than +1239A homozygotes and a higher risk of developing autoimmune/lymphoproliferative syndrome, multiple sclerosis, and systemic lupus erythematosus.
|
20378012 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Recent insights into the genetic basis of systemic lupus erythematosus.
|
19440199 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study provides a biologic relevance for OPN variants at the protein level, and suggests an influence of this gene on the IFN-alpha pathway in SLE.
|
19339987 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
The present study evaluates association between SPP1 polymorphisms and SLE in a large cohort of 1141 unrelated SLE patients [707 European-American (EA) and 434 African-American (AA)], and 2009 unrelated controls (1309 EA and 700 AA).
|
18335026 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.
|
18335026 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
OPN gene 9250 polymorphism appears to be associated with susceptibility to SLE in Chinese Han ethnic population.
|
18167187 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
We can speculate that these sequence variants (or others in perfect linkage disequilibrium) create a predisposition to high production of OPN, and that this in turn may confer susceptibility to SLE.
|
15692970 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that, unlike the reported effect of the OPN SNP conferring predisposition to common diseases such as multiple sclerosis or systemic lupus erythematosus, these OPN gene polymorphisms do not contribute to RA susceptibility in the Spanish population we studied.
|
15742429 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We can speculate that these sequence variants (or others in perfect linkage disequilibrium) create a predisposition to high production of OPN, and that this in turn may confer susceptibility to SLE.
|
15692970 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
It has been said that macrophage metalloelastase is related to ulcer formation of the intestine, whereas osteopontin plays an important role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis.
|
12842452 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE.
|
11933203 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE.
|
11933203 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE.
|
11933203 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Glomerular expression of osteopontin in biopsies of human crescentic glomerulonephritis (N = 25), IgA nephropathy with crescents (N = 2), and diffuse proliferative lupus glomerulonephropathy with crescents (N = 1) was studied by immunohistochemistry, in situ hybridization, and combined immunohistochemistry/in situ hybridization.
|
10620192 |
2000 |