Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is identified as a diagnostic and prognostic biomarker of tumor progression and metastasis.
|
31792339 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate a novel mechanism of tumor progression mediated by OPN released in response to chemotherapy-generated tumor cell debris.
|
29957058 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (SPP1) is a key extracellular matrix protein involved in several pathophysiological processes including cancer progression and metastasis.
|
31500540 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN), also known as SPP1 (secreted phosphoprotein 1), a secreted and chemokine-like glyco-phosphoprotein is involved in tumor progression such as cell proliferation, angiogenesis, and metastasis.
|
31028902 |
2019 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid and non‑solid tumors.
|
30535434 |
2019 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues.
|
30177680 |
2018 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression.
|
30542698 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we focused on the therapeutic role of osteopontin (OPN), a secreted glycosylated phosphoprotein, involved in a number of physiological events including bone formation and remodeling, immune responses, and tumor progression.
|
29110207 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a promoter for tumor progression.
|
29535539 |
2018 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Osteopontin (OPN) spliced variants (OPN-SV: OPNa, OPNb, and OPNc) are aberrantly expressed in tumors and frequently associated with cancer progression.
|
30274371 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Loss of microenvironment-derived OPN enhanced tumor progression.
|
29016864 |
2018 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present study detected the expression levels of OPN and evaluated its role in tumor progression in patients with non-small cell lung cancer (NSCLC).
|
30275702 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a glycoprotein involved in regulation of various influences on tumor progression, such as
|
29580029 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression.
|
28769537 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
There is growing evidence to suggest that osteopontin (OPN) may play a critical role in tumor progression and metastasis.
|
27578008 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In various adult neoplasms OPN was shown to correlate with cancer progression, invasiveness and metastasis.
|
28326824 |
2017 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression.
|
28505114 |
2017 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Osteopontin splice variants and polymorphisms in cancer progression and prognosis.
|
28254527 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive.
|
29209142 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Extensive studies have elucidated the critical role of OPN in cell signaling such as regulation of cell proliferation, migration, inflammation, fibrosis and tumor progression.
|
27570486 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a phosphoprotein that activates several aspects of tumor progression.
|
26404131 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer.
|
26509489 |
2015 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies.
|
25824779 |
2015 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas, suggesting a relevant role in the pathogenesis and tumor progression of this molecular subtype.
|
25972323 |
2015 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We have previously demonstrated that CBX7 is able to inhibit the expression of the SPP1 gene, encoding the chemokine osteopontin that is over-expressed in cancer and has a critical role in cancer progression.
|
25595895 |
2015 |