SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE It may be noted that despite being a strong marker to identify human tumor metastasis, no study on effect of artemisinin and its synthetic and semisynthetic derivatives on OPN expression has ever been studied. 31791643 2020
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE Furthermore, high levels of OPN were detected in vesicles derived from rats harboring breast cancer skeletal metastases. 31590218 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE Increased accumulation of the targeted NPs was achieved in the primary mammary tumor of mice xenografted with MDA-MB-231 mammary carcinoma cells as well as in the lungs, one of the main sites affected by metastases. siOPN NPs treatment resulted in significant inhibition of tumor growth (similar bioactivity of both formulations), accompanied with significant reduction of OPN mRNA levels (~40% knockdown of mRNA levels). 30934857 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE Importantly, JNK inhibition or disruption of SPP1 or TNC expression sensitizes experimental mammary tumors and metastases to chemotherapy, thus providing insights to consider for future treatment strategies against metastatic breast cancer. 30190333 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Collectively, our results indicate that the OPN-CCR1 axis in HCC is important for accelerating tumor metastasis and that CCR1 is a potential therapeutic target for controlling metastasis in HCC patients with high OPN. 29285854 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Osteopontin is related to tumor metastasis and proliferation. 25725928 2015
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. 26509489 2015
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE The number of extrapulmonary metastases was significantly higher in the high-SPP1-expressing patients than in the low-expressing patients (P = 0.03). 24758329 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE OPN is associated with tumor metastasis of several tumors and is overexpressed in hepatocellular carcinoma (HCC) tissue involving HCC invasion and metastasis. 24240095 2013
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE The consistency of OPN transcriptional control between primary CRC and metastases is unclear. 21343932 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE However, the mechanisms by which OPN promotes tumor metastasis remain unclear. 21286666 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE Taken together, these data suggest that OPN is an ERG-target gene in PCa where the abnormal expression of the transcription factor ERG, due to the TMPRSS2:ERG fusion, disturbs the expression of genes that play an important role in PCa cells and associated metastases. 21669963 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of several carcinoma types. 21207061 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE In conclusion, Expression of OPN in the tissue of HCC is related to metastasis or metastases. 21188534 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE These findings suggest that OPN-targeted therapy may be a promising strategy for the treatment of HCC metastases. 21174062 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of hepatocellular cancer (HCC). 20576283 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with cell proliferation and tumor metastatic spread in a variety of cancers. 20207476 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE We showed recently that nicotine induces osteopontin (OPN), a protein that plays critical roles in inflammation and tumor metastasis. 20579680 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Further study demonstrated that VEGF/OPN-BsAb could effectively suppress primary tumor growth and metastasis to lungs, suggesting that it might be a promising therapeutic agent for treatment of metastatic cancer. 20826049 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 GeneticVariation group BEFREE As shown by real-time PCR analysis, melanoma metastases that were homozygous for the -443C allele expressed significantly higher levels of OPN mRNA compared with those that were either heterozygous (-443T/C) or homozygous for the -443T allele. 18459127 2009
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE In addition, DLC1 down-regulated the expression of osteopontin and matrix metalloproteinase-9, which are highly up-regulated in most primary HCC with associated metastases. 18497990 2008
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 AlteredExpression group BEFREE Here we report that TIP30 suppresses metastasis of hepatocellular carcinoma (HCC) through inhibiting the transcription of osteopontin (OPN), a key molecule in the development of tumor metastasis. 18537194 2008
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE OPN has been linked with tumor metastasis and signifies a poor prognosis for the patient. 18508515 2008
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE In SW480 human colon cancer cells, we conclude that Sp1 mediated expression of the tumor metastasis protein, OPN, regulates in vitro functional correlates of tumor metastasis. 17689681 2007
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.100 Biomarker group BEFREE Suppression of OPN may be one of the possible underlying mechanisms of BRMS1-dependent suppression of tumor metastasis. 17227585 2007