Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that a potential tumor suppressor gene(s) may reside in the < 2 Mb region centromeric (inclusive) to the BRCA1 gene and that this tumor suppressor gene(s) may be involved in the formation of prostate cancer.
|
7478543 |
1995 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of polymorphic loci on 17q in the series of hybrid clones suggested that a tumor suppressor gene associated with prostate cancer was located in a region no more than 28 cM long at 17q12-q22, which includes the BRCA1 gene involved in hereditary breast cancer.
|
7614477 |
1995 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the BRCA1 and/or other genes within the interval between BRCA1 and D17S856 on 17q21 may be important in the pathogenesis of prostate cancer.
|
7866981 |
1995 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data suggest that the region distal to BRCA1 may contain 1 or more prostate-specific tumor suppressor genes and that BRCA1 itself plays only a minor role in prostate cancer development.
|
8558713 |
1996 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further evidence comes from the increased risk of prostate cancer in BRCA1 mutation carriers but more particularly from the recent report of the mapping of a prostate cancer susceptibility gene to chromosome 1.
|
9299581 |
1997 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four microsatellite polymorphic markers (D8S133, D8S136, and D8S137, for a putative tumor suppressor gene on chromosome 8p, and D17S855, for the BRCA1 gene on chromosome 17q) were used to examine the pattern of allelic loss in prostate cancer from 19 patients who had two or more distantly separate tumors (i.e., located on contralateral sides or separated by at least half the anterior-posterior diameter of the prostate).
|
9462681 |
1998 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We stably expressed wild-type (wt) and tumor-associated mutant BRCA1 transgenes in DU-145, a human prostate cancer cell line with low endogenous expression of BRCA1.
|
9662340 |
1998 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chromosome 1 (HPC1) has been proposed on the basis of linkage analysis.
|
9690990 |
1998 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested for the BRCA1 185delAG frameshift mutation, found in 0.9% of Ashkenazi Jews, and the BRCA2 6174delT mutation, found in 1% of Ashkenazi Jews, in Ashkenazi Jewish men with prostate cancer.
|
9743298 |
1998 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that microsatellite instability and loss of unidentified genes on chromosome 8p may be involved in carcinogenesis of the prostate; however, BRCA1 and BRCA2 may not be largely involved in the development of prostate cancer in the Japanese population.
|
9778625 |
1998 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It appears that the BRCA1 gene is not frequently involved in the development of primary prostate cancer.
|
9988226 |
1999 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer.
|
10344217 |
1999 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies indicate that beclin 1 maps to a region approximately 150 kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer.
|
10395800 |
1999 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This suggests that unlike cases of breast and ovarian cancers, mutations in BRCA1 or BRCA2 do not significantly predispose men to prostate cancer.
|
10398279 |
1999 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 mutation detection was performed on a family having four confirmed cases of ovarian cancer, two cases of breast cancer, and one case each of colon, stomach, and prostate cancer.
|
10600309 |
1999 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, 22 high-risk prostate cancer families (at least three cases of prostate cancer) were screened by conformation-sensitive gel electrophoresis (CSGE) for mutations in BRCA1 and BRCA2.
|
10728701 |
2000 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 gene mutations may also be related with other types of cancers such as prostate cancer and colorectal cancer.
|
10810408 |
2000 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, no allelic losses at the BRCA1 locus were demonstrated in 17 patients with a family history of CaP, using seven microsatellite markers.
|
10945492 |
2000 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Blood DNA from affected individuals in 38 prostate cancer clusters was analyzed for germ-line mutations in BRCA1 and BRCA2 to assess the contribution of each of these genes to familial prostate cancer.
|
10969800 |
2000 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Examination of other breast and prostate cancer cell lines revealed that sensitivity to the anti-proliferative effects of 1alpha, 25(OH)2D3 was strongly associated with an ability to modulate BRCA1 protein.
|
11042697 |
2000 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germ-line mutations of the breast cancer susceptibility gene 1 (BRCA1) confer a high risk for breast and ovarian cancer in women and prostate cancer in men.
|
11163768 |
2001 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The BRCA1 gene was previously found to inhibit the transcriptional activity of the estrogen receptor [ER-alpha] in human breast and prostate cancer cell lines.
|
11244506 |
2001 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A second breast cancer susceptibility gene (BRCA2) operates in some of the same molecular pathways as BRCA1, and mutations of this gene predispose to breast and ovarian cancer and probably to other tumor types, including prostate cancer.
|
11405179 |
2001 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that expression of the breast cancer susceptibility gene BRCA1 strongly inhibits the transcriptional activity of the estrogen receptor (ER-alpha) in human breast and prostate cancer cell lines but only weakly inhibits ER-alpha activity in cervical cancer cells (S. Fan et al., Science (Wash. DC), 284: 1354-1356, 1999).
|
11782371 |
2002 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Early age at diagnosis of breast cancer, ovarian cancer, bilateral breast cancer, concomitant breast/ovarian cancer in a single patient and prostate cancer but not unilateral breast cancer were associated with BRCA1 and BRCA2 mutations.
|
11802208 |
2002 |