|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results suggest that a potential tumor suppressor gene(s) may reside in the < 2 Mb region centromeric (inclusive) to the BRCA1 gene and that this tumor suppressor gene(s) may be involved in the formation of prostate cancer.
|
7478543 |
1995 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of polymorphic loci on 17q in the series of hybrid clones suggested that a tumor suppressor gene associated with prostate cancer was located in a region no more than 28 cM long at 17q12-q22, which includes the BRCA1 gene involved in hereditary breast cancer.
|
7614477 |
1995 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the BRCA1 and/or other genes within the interval between BRCA1 and D17S856 on 17q21 may be important in the pathogenesis of prostate cancer.
|
7866981 |
1995 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
The data suggest that the region distal to BRCA1 may contain 1 or more prostate-specific tumor suppressor genes and that BRCA1 itself plays only a minor role in prostate cancer development.
|
8558713 |
1996 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further evidence comes from the increased risk of prostate cancer in BRCA1 mutation carriers but more particularly from the recent report of the mapping of a prostate cancer susceptibility gene to chromosome 1.
|
9299581 |
1997 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four microsatellite polymorphic markers (D8S133, D8S136, and D8S137, for a putative tumor suppressor gene on chromosome 8p, and D17S855, for the BRCA1 gene on chromosome 17q) were used to examine the pattern of allelic loss in prostate cancer from 19 patients who had two or more distantly separate tumors (i.e., located on contralateral sides or separated by at least half the anterior-posterior diameter of the prostate).
|
9462681 |
1998 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We stably expressed wild-type (wt) and tumor-associated mutant BRCA1 transgenes in DU-145, a human prostate cancer cell line with low endogenous expression of BRCA1.
|
9662340 |
1998 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chromosome 1 (HPC1) has been proposed on the basis of linkage analysis.
|
9690990 |
1998 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We tested for the BRCA1 185delAG frameshift mutation, found in 0.9% of Ashkenazi Jews, and the BRCA2 6174delT mutation, found in 1% of Ashkenazi Jews, in Ashkenazi Jewish men with prostate cancer.
|
9743298 |
1998 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data suggest that microsatellite instability and loss of unidentified genes on chromosome 8p may be involved in carcinogenesis of the prostate; however, BRCA1 and BRCA2 may not be largely involved in the development of prostate cancer in the Japanese population.
|
9778625 |
1998 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
It appears that the BRCA1 gene is not frequently involved in the development of primary prostate cancer.
|
9988226 |
1999 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer.
|
10344217 |
1999 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous studies indicate that beclin 1 maps to a region approximately 150 kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer.
|
10395800 |
1999 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This suggests that unlike cases of breast and ovarian cancers, mutations in BRCA1 or BRCA2 do not significantly predispose men to prostate cancer.
|
10398279 |
1999 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 mutation detection was performed on a family having four confirmed cases of ovarian cancer, two cases of breast cancer, and one case each of colon, stomach, and prostate cancer.
|
10600309 |
1999 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, 22 high-risk prostate cancer families (at least three cases of prostate cancer) were screened by conformation-sensitive gel electrophoresis (CSGE) for mutations in BRCA1 and BRCA2.
|
10728701 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 gene mutations may also be related with other types of cancers such as prostate cancer and colorectal cancer.
|
10810408 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, no allelic losses at the BRCA1 locus were demonstrated in 17 patients with a family history of CaP, using seven microsatellite markers.
|
10945492 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Blood DNA from affected individuals in 38 prostate cancer clusters was analyzed for germ-line mutations in BRCA1 and BRCA2 to assess the contribution of each of these genes to familial prostate cancer.
|
10969800 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated.
|
11016951 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Examination of other breast and prostate cancer cell lines revealed that sensitivity to the anti-proliferative effects of 1alpha, 25(OH)2D3 was strongly associated with an ability to modulate BRCA1 protein.
|
11042697 |
2000 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings indicate that BRCA1 interacts with the components of the JAK-STAT signaling cascade and modulates its activation, which may provide a new critical survival signal for the growth of breast, ovarian and prostate cancers in the presence of normal BRCA1.
|
11163768 |
2001 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The BRCA1 gene was previously found to inhibit the transcriptional activity of the estrogen receptor [ER-alpha] in human breast and prostate cancer cell lines.
|
11244506 |
2001 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A second breast cancer susceptibility gene (BRCA2) operates in some of the same molecular pathways as BRCA1, and mutations of this gene predispose to breast and ovarian cancer and probably to other tumor types, including prostate cancer.
|
11405179 |
2001 |