|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
[Simple and rapid technic of grouping of streptococci].
|
824983 |
1976 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
[The measuring for depth of papillary excavation by microcomputer (author's transl)].
|
7257965 |
1980 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Chromosome damage in G0 X-irradiated lymphocytes from patients with hereditary retinoblastoma.
|
6455195 |
1981 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Purification and characterization of a new sodium-transport decarboxylase. Methylmalonyl-CoA decarboxylase from Veillonella alcalescens.
|
6852015 |
1983 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Diagnosis of vertebral fractures.
|
6848529 |
1983 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
AIDS legislation.
|
3175448 |
1988 |
|
Mammary Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes.
|
7680524 |
1993 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer.
|
7894491 |
1994 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We analyzed 14 ovarian and breast tumors from BRCA1 carriers and 1 sporadic breast tumor from 3 kindreds for 17q21 LOH.
|
7954448 |
1994 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The most frequently deleted region overlaps with the minimal region containing the BRCA1 gene, suggesting that this gene might also be associated with the development or progression of a proportion of sporadic breast tumours.
|
7529047 |
1994 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We have studied chromosomal deletions in the BRCA1 region in seven breast tumors, three ovarian tumors, one bladder cancer, and one colon cancer from patients in six families with breast-ovarian cancer, in order to test the hypothesis of the tumor suppressor mechanism at this locus.
|
8076936 |
1994 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Previous studies of loss of heterozygosity (LOH) in breast tumors have been carried out on sporadic tumors derived from individuals without known linkage to BRCA1 and on tumors from linked families.
|
9816013 |
1995 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Approximately 90% of breast tumors in BRCA1 families, 50% of unselected breast tumors and 65-80% of unselected ovarian tumors have lost one allele of BRCA1 by somatic deletion.
|
8541881 |
1995 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
The BRCA1 positive breast tumours were significantly more often of ductal type, histological grade III and manifested a heavy lymphocyte infiltration.
|
9155518 |
1997 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Nevertheless, BRCA1 activity is markedly decreased in invasive breast tumors.
|
9269993 |
1997 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Such a complex could explain at a molecular level the "increase in NF-kappaB DNA binding activity" often observed in c-erbB-2- and BRCA1-positive human breast tumors.
|
9188464 |
1997 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Since BRCA1 mutations found in breast tumours are invariably germline, two immediate consequences are apparent.
|
9274454 |
1997 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Pathology of sporadic breast tumors with LOH at the BRCA1 locus: correlation with histopathological features specific to familial BRCA1 tumors and absence of microsatellite instability.
|
9592202 |
1998 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
BRCA1 is considered to be a tumor-suppressor gene, yet mutations in this gene are uncommon in sporadic breast tumors.
|
9639385 |
1998 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Decreased BRCA1 expression levels may arrest the cell cycle through activation of p53 checkpoint in human sporadic breast tumors.
|
9535786 |
1998 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Breast tumours from BRCA1 and BRCA2 mutation carriers are genetically instable and display specific patterns of chromosomal aberrations, suggestive of distinct genetic pathways in tumour progression.
|
9467939 |
1998 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BRCA1- and BRCA2-related breast tumors were distinct in their expression of steroid receptors.
|
9669814 |
1998 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These data suggest that aberrant DNA methylation at regulatory sequences in the BRCA1 locus may play a role in the transcriptional inactivation of the BRCA1 gene within subclones of breast tumors.
|
9528858 |
1998 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours.
|
9796697 |
1998 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A statistically significantly higher frequency of p53 mutations was found in breast tumors from carriers of BRCA1 mutations than from noncarriers, which adds to the accumulating evidence that loss of p53 function is an important step in the molecular pathogenesis of BRCA1 mutation-associated breast tumors.
|
10070948 |
1999 |