BRCA1, BRCA1 DNA repair associated, 672

N. diseases: 747; N. variants: 2600
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. 15829967 2005
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. 11406561 2001
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. 10198641 1999
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Brca1 controls homology-directed DNA repair. 10549283 1999
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. 10602489 1999
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. 9774970 1998
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Growth retardation and tumour inhibition by BRCA1. 8589721 1996
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. 7795653 1995
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium. 7669740 1995
CUI: C2676677
Disease: BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 		0.300 Biomarker phenotype CLINGEN A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. 7545954 1994