Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that steatosis in HNF1alpha-mutated HCA results mainly from an aberrant promotion of lipogenesis that is linked to HNF1alpha inactivation and that is independent of both SREBP-1 and ChREBP activation.
|
17379603 |
2007 |
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.
|
17484888 |
2007 |
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice.
|
18627005 |
2008 |
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that steatosis in patients infected with HCVGT3 is not the result of a sustained SREBF1 driven increase in expression of genes involved in lipogenesis.
|
20196803 |
2011 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
They also show that the SREBP1-mediated induction of hepatic steatosis in ob/ob mice requires Gpat1.
|
20200319 |
2010 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation.
|
21105651 |
2010 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study investigated the role of the adenosine monophosphate-activated protein kinase (AMPK)-sterol regulatory element-binding protein-1 (SREBP-1) pathway in the OA-induced fatty liver.
|
21757781 |
2011 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using miR-33(-/-)Srebf1(+/-) mice, we demonstrate that SREBP-1 is a target of miR-33 and that the mechanisms leading to obesity and liver steatosis in miR-33(-/-) mice involve enhanced expression of SREBP-1.
|
24300912 |
2013 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
A simple transcriptomic signature able to predict drug-induced hepatic steatosis.
|
24469900 |
2014 |
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway.
|
25087956 |
2014 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, our data suggest that activation and knockdown of PXR in human hepatic cells promote de novo lipogenesis and steatosis by induction of the SREBP1 pathway and AKR1B10-mediated increase of ACC activity, respectively, thus providing mechanistic explanations for a putative dual role of PXR in the pathogenesis of steatohepatitis.
|
25182422 |
2015 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
FK866 significantly promoted liver steatosis in the mice fed with HFD and hepatic lipid accumulation in vitro, accompanied by the increases of the expressions of lipogenic genes such as sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN).
|
28449683 |
2017 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.
|
28483554 |
2017 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The improvement of hepatic steatosis observed in DIO-treated mice was associated with a decrease in the hepatic content of SREBP-1, a transcription factor involved in de novo lipogenesis.
|
28557705 |
2017 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study unveils an H19/PTBP1/sterol regulatory element-binding protein 1 feedforward amplifying signaling pathway to exacerbate the development of fatty liver.(Hepatology 2018;67:1768-1783).
|
29140550 |
2018 |
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Loss of Pgrmc1 increased mature SREBP-1 protein level, suggesting that induction of hepatic steatosis in Pgrmc1 KO mice might be triggered by de novo lipogenesis.
|
30356113 |
2018 |
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, dietary BA enhanced the growth and alleviated liver fibrosis induced by a high starch diet to steatohepatitis/recovery symptom via improving glucose and lipid metabolism, which regulated by AKT/FOXO1 and cAMP/AMPK/SREBP1 pathway in largemouth bass.
|
31824338 |
2019 |