Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 Biomarker disease BEFREE Functionally SREBP1 promotes growth and metastasis of breast cancer both in vitro and in vivo. 29988076 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 Biomarker disease BEFREE SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer. 31073170 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 Biomarker disease BEFREE The present study found that treatment of breast cancer MDA-MB-231 cells with metformin significantly decreased cholesterol content with concomitant inhibition of various cholesterol regulatory genes (e.g., HMGCoR, LDLR and SREBP1). 30625181 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 Biomarker disease BEFREE Finally, in silico expression analysis in clinical specimens from a neo-adjuvant endocrine trial showed a significant association between the increase of SREBP1 expression and lack of clinical response, providing further support for a role of SREBP1 in the acquisition of endocrine resistance in breast cancer. 30180878 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 AlteredExpression disease BEFREE Fibroblast/breast cancer cell co-cultures were set up to investigate the influence of NFs and CAFs on gene and protein expression of Stearoyl-CoA desaturase 1 (SCD1), the main enzyme regulating membrane fluidity, as well as on the protein level and activity of its transcription factor, the sterol regulatory element-binding protein 1 (SREBP1), in MCF-7 and MDA-MB-231 cells. 25880005 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.160 GeneticVariation disease BEFREE We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). 19252981 2009