|
Malignant neoplasm of breast
|
0.530 |
Biomarker
|
disease |
CTD_human |
Collectively, our results suggest that SREBP-2 plays a critical role in regulating osteoclastogenesis and contributes to breast cancer-induced osteolysis.
|
30394316 |
2019 |
|
Malignant neoplasm of breast
|
0.530 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggest that SREBP-2 plays a critical role in regulating osteoclastogenesis and contributes to breast cancer-induced osteolysis.
|
30394316 |
2019 |
|
Malignant neoplasm of breast
|
0.530 |
Biomarker
|
disease |
BEFREE |
SREBP2 knockdown in lung and breast cancer cells completely abrogated the fluvastatin-induced upregulation of sterol-responsive genes HMGCR and HMGCS1.
|
26353928 |
2015 |
|
Malignant neoplasm of breast
|
0.530 |
Biomarker
|
disease |
BEFREE |
Similarly, the mRNA levels for FAS and SREBP-1c in a panel of primary human breast cancer samples showed much greater increases than did those for SREBP-1a and SREBP-2 and were significantly correlated with each other, suggesting coordinate regulation of SREBP-1c and FAS in clinical breast cancer.
|
12531699 |
2003 |
|
Malignant neoplasm of breast
|
0.530 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Kidney Failure, Chronic
|
0.500 |
Biomarker
|
disease |
CTD_human |
CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A.
|
19878707 |
2010 |
|
Kidney Failure, Chronic
|
0.500 |
Biomarker
|
disease |
RGD |
Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats.
|
16814791 |
2007 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
BEFREE |
We found that a subset of lipid-related genes was nominally associated with schizophrenia (p = 0.037), but this signal did not survive multiple testing correction (FWER = 0.16) and was mainly driven by the SREBF1 and SREBF2 genes that have already been linked to schizophrenia.
|
29720671 |
2018 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
BEFREE |
Here we review the evidence for the involvement of SREBF1 and SREBF2 as genetic risk factors in schizophrenia and discuss the role of myelination and SREBP-mediated lipid biosynthesis in the etiology, pathophysiology and drug treatment of schizophrenia.
|
27492885 |
2017 |
|
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Ten single nucleotide polymorphisms (SNPs) of SREBF2 were genotyped in a CHB (Han Chinese in Beijing, China) population, a sample of 621 schizophrenia patients treated with clozapine.
|
25201120 |
2015 |
|
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
We therefore conducted a HapMap-based association study in a large German sample, and identified association between schizophrenia and five markers in SREBF1 and five markers in SREBF2.
|
18936756 |
2010 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
We therefore conducted a HapMap-based association study in a large German sample, and identified association between schizophrenia and five markers in SREBF1 and five markers in SREBF2.
|
18936756 |
2010 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggest that SREBP-2 plays a critical role in regulating osteoclastogenesis and contributes to breast cancer-induced osteolysis.
|
30394316 |
2019 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Collectively, our results suggest that SREBP-2 plays a critical role in regulating osteoclastogenesis and contributes to breast cancer-induced osteolysis.
|
30394316 |
2019 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Its overexpression in hepatocellular carcinoma impairs cholesterol homeostasis due to the altered activation of the sterol regulatory element-binding protein (SREBP) 2, which results in the accumulation of cellular cholesteryl esters (CE).
|
30448348 |
2019 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Cancer genomics analysis indicated that SREBP2 upregulation was associated with the poor overall survival of HCC patients.
|
31720078 |
2019 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
By contrast, increased SREBP‑2 partly restored the inhibited autophagic activity in lipid‑overloaded hepatoma HepG2 cells.
|
29336468 |
2018 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
SREBP2 knockdown in lung and breast cancer cells completely abrogated the fluvastatin-induced upregulation of sterol-responsive genes HMGCR and HMGCS1.
|
26353928 |
2015 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
In HCC cell lines, the AKT-mammalian target of rapamycin complex 1-ribosomal protein S6 pathway promoted lipogenesis via transcriptional and post-transcriptional mechanisms that included inhibition of fatty acid synthase ubiquitination by the USP2a de-ubiquitinase and disruption of the SREBP1 and SREBP2 degradation complexes.
|
21147110 |
2011 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Similarly, the mRNA levels for FAS and SREBP-1c in a panel of primary human breast cancer samples showed much greater increases than did those for SREBP-1a and SREBP-2 and were significantly correlated with each other, suggesting coordinate regulation of SREBP-1c and FAS in clinical breast cancer.
|
12531699 |
2003 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
In this study, we demonstrated that important roles sterol regulatory element-binding protein 2 (SREBP-2) play in osteoclast formation a function, and in breast cancer metastasis.
|
30394316 |
2019 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
SREBP-2 was similarly under the transcriptional control of CREB and its induction regulates the expression of matrix metalloproteinases (MMPs), key degradative enzymes involved in bone metastases by breast cancer cells.
|
30394316 |
2019 |
|
Neoplasm Metastasis
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
They can act as either tumor suppressors or oncogenes, and changes in their levels are associated with tumor initiation, progression and metastasis. miR-33a is an intronic miRNA embedded within SREBF2 that has been reported to have tumor suppressive properties in some cancers but has not been examined in prostate cancer.
|
28947967 |
2017 |
|
Hypercholesterolemia, Familial
|
0.310 |
Biomarker
|
disease |
BEFREE |
We aimed to identify new single-nucleotide variants (SNVs) located at the 3' untranslated regions (3'UTRs) of the low-density lipoprotein receptor, low-density lipoprotein receptor-related protein-associated protein 1, ATP-binding cassette sub-family G member 5, and sterol regulatory element-binding protein 2 genes in non-FH-GH individuals and investigated whether the association of these SNVs with non-FH-GH could be explained by changes in the affinity of regulatory microRNAs (miRNA) targeting the sequences modified by the SNVs.
|
28502511 |
2018 |
|
Hypercholesterolemia, Familial
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Identification of mutations in the gene encoding sterol regulatory element binding protein (SREBP)-2 in hypercholesterolaemic subjects.
|
11950857 |
2002 |