SRF, serum response factor, 6722

N. diseases: 147; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation group BEFREE A fusion between SRF exon 4 and ICA1L exon 10 or 11 was identified in a total of 4 spindle cell tumors with similar clinicopathologic features. 31478943 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE FA-modified albumin nanoparticles are good carriers for delivering SRF to the tumor tissue, which can improve the therapeutic effect and reduce the side effects of the drug. 30744448 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE This results in enhanced SRF-dependent transcriptional activity and promotes tumor cell growth and invasion. 30371874 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation group BEFREE Binding of LNC CRYBG3 to G-actin blocked nuclear localization of MAL, which consequently kept serum response factor (SRF) away from the promoter region of several immediate early genes, including JUNB and Arp3, which are necessary for cellular proliferation, tumor growth, adhesion, movement, and metastasis. 29934435 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE In addition, miR-101-3p could directly target and suppress the expression of the serum response factor (SRF) gene, which is a transcription factor of HOTAIR, a well-characterized tumor promoter lncRNA. miR-101-3p negatively regulated SRF-mediated transcription of HOTAIR. 28251884 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE In vivo anticancer analysis results clearly suggest that nanoparticle encapsulation of combination of SRF and miRNA (with miRNA) will have greater antitumor efficacy in tumor mice. 29181687 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype. 28114277 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Recent studies have indicated that SRF plays a role in the development of some tumors, including hepatocellular, thyroid, esophageal, and lung carcinomas. 23134219 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Expression of SRF or Igf1R partially reversed tumor suppressor function of miR-122. 19726678 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE SRF expression correlated with the tumor size of the PTCs (P<0.05). 19513551 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE We defined a new role of SRF as a nuclear repressor of the tumor growth factor beta1 (TGF-beta1) growth-inhibitory signal during cell proliferation. 16819512 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Therapeutic group CTD_human Cellular toxicity induced by SRF-mediated transcriptional squelching. 17116645 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 AlteredExpression group BEFREE The majority of these SRF/IGF2BP1-enhanced genes, including PDLIM7 and FOXK1, show conserved upregulation with SRF and IGF2BP1 synthesis in cancer. 30371874 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 AlteredExpression group BEFREE Analysis of the immunohistochemical staining of benign versus cancer cores showed higher expression of nuclear SRF protein expression in cancer cores compared with benign for all the three TMAs analysed (P < 0.001, n = 615). 29608018 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 AlteredExpression group BEFREE We show that the MRTF-SRF pathway is activated in cancer-associated fibroblasts (CAFs). 29317486 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 AlteredExpression group BEFREE MKL1 and SRF were further demonstrated to promote the expression of <i>IL11</i>, which is essential for miR-206's function in inhibiting both invasion and stemness of breast cancer.<b>Conclusions:</b> The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis.<i>Clin Cancer Res; 23(4); 1091-103.©2016 AACR</i>. 27435395 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 Biomarker group BEFREE MRTF-A, co-activators of serum response factor (SRF), promoted tumor cell invasion and metastasis in cancer. 28035058 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 Biomarker group BEFREE We discovered a breast cancer-specific set of genes including tenascin-C, which is regulated by Mkl1 in a SAP domain-dependent, serum response factor-independent manner and is strongly implicated in cell proliferation, cell motility and cancer. 24495796 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 AlteredExpression group BEFREE Consistent with its role as a Rho/SRF pathway inhibitor, CCG-1423 displays activity in several in vitro cancer cell functional assays. 17699722 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 Therapeutic group CTD_human These findings suggest transcriptional squelching may be engineered for killing cancer cells, and the SRF gene may represent a novel molecular target for cancer therapeutics. 17116645 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.380 Biomarker group BEFREE This is the first study to document a change in expression of the alternatively spliced isoform of SRF in human malignancy. 15313381 2004
CUI: C0015923
Disease: Fetal Alcohol Syndrome
Fetal Alcohol Syndrome
0.300 Biomarker disease PSYGENET These findings suggest that overexpression of SRF exclusively in astrocytes can improve neuronal plasticity in FASD. 22742904 2012
CUI: C2985290
Disease: Fetal Alcohol Spectrum Disorders
Fetal Alcohol Spectrum Disorders
0.300 Biomarker group PSYGENET These findings suggest that overexpression of SRF exclusively in astrocytes can improve neuronal plasticity in FASD. 22742904 2012
CUI: C0015923
Disease: Fetal Alcohol Syndrome
Fetal Alcohol Syndrome
0.300 Biomarker disease PSYGENET Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. 20164336 2010
CUI: C2985290
Disease: Fetal Alcohol Spectrum Disorders
Fetal Alcohol Spectrum Disorders
0.300 Biomarker group PSYGENET Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. 20164336 2010