|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that one of the SRF-regulated neuronal IEGs, activity-regulated cytoskeleton-associated protein (Arc; also termed Arg3.1), is regulated by an SRF coactivator, megakaryoblastic leukemia (MKL).
|
30244496 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together regulate transcription of actin cytoskeleton genes.
|
31582539 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Active SRF along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity.
|
29400712 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
The megakaryoblastic leukaemia (MKL) family are serum response factor (SRF) coactivators, which are highly expressed in the brain.
|
29335431 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1 and MKL2) and their role in controlling VSMC and EC proliferation and migration.
|
28623279 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β-induced TNS1 expression is dependent on signaling through the TGF-β receptor 1 and is Rho coiled-coiled kinase/actin/megakaryoblastic leukemia-1/serum response factor dependent.
|
28005397 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we provide initial evidence supporting the ability of Pfn to influence MKL and SRF expression.
|
28546428 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
De novo synthesis of cytoskeleton-regulatory proteins triggered by the megakaryoblastic leukemia (MKL)/serum response factor (SRF) transcriptional system in response to pro-angiogenic growth factors lies at the heart of endothelial cell (EC) migration (a critical element of angiogenesis) and neovascularization.
|
28638990 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell.
|
26554816 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, application of dynamic strain or matrix stiffness to 4T1 cells converted the predominant SRF/Mkl1 action into SAP domain-dependent Mkl1 signaling independent of SRF, accompanied by a switch to SAP-dependent tumor cell migration.
|
25999144 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), also known as MAL or myocardin-related transcription factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of actin and actin cytoskeleton-related genes.
|
26224645 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β promoted a delayed nuclear accumulation of the SRF coactivator megakaryoblastic leukemia-1 (MKL1)/myocardin-related transcription factor-A, which was inhibited by latrunculin B.
|
21856814 |
2011 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF).
|
19136660 |
2009 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysophosphatidic acid receptors stimulate a Galpha(12/13)/RhoA-dependent gene transcription program involving the serum response factor (SRF) and its coactivator and oncogene, megakaryoblastic leukemia 1 (MKL1).
|
17699722 |
2007 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extracellular signals regulate Srf in part via a pathway involving megakaryoblastic leukemia 1 (Mkl1, also known as myocardin-related transcription factor A [Mrtf-a]), which coactivates Srf-responsive genes downstream of Rho GTPases.
|
16847333 |
2006 |