|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A fusion between SRF exon 4 and ICA1L exon 10 or 11 was identified in a total of 4 spindle cell tumors with similar clinicopathologic features.
|
31478943 |
2020 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
FA-modified albumin nanoparticles are good carriers for delivering SRF to the tumor tissue, which can improve the therapeutic effect and reduce the side effects of the drug.
|
30744448 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This results in enhanced SRF-dependent transcriptional activity and promotes tumor cell growth and invasion.
|
30371874 |
2019 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Binding of LNC CRYBG3 to G-actin blocked nuclear localization of MAL, which consequently kept serum response factor (SRF) away from the promoter region of several immediate early genes, including JUNB and Arp3, which are necessary for cellular proliferation, tumor growth, adhesion, movement, and metastasis.
|
29934435 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, miR-101-3p could directly target and suppress the expression of the serum response factor (SRF) gene, which is a transcription factor of HOTAIR, a well-characterized tumor promoter lncRNA. miR-101-3p negatively regulated SRF-mediated transcription of HOTAIR.
|
28251884 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In vivo anticancer analysis results clearly suggest that nanoparticle encapsulation of combination of SRF and miRNA (with miRNA) will have greater antitumor efficacy in tumor mice.
|
29181687 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype.
|
28114277 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Recent studies have indicated that SRF plays a role in the development of some tumors, including hepatocellular, thyroid, esophageal, and lung carcinomas.
|
23134219 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of SRF or Igf1R partially reversed tumor suppressor function of miR-122.
|
19726678 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
SRF expression correlated with the tumor size of the PTCs (P<0.05).
|
19513551 |
2009 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We defined a new role of SRF as a nuclear repressor of the tumor growth factor beta1 (TGF-beta1) growth-inhibitory signal during cell proliferation.
|
16819512 |
2007 |
|
Neoplasms
|
0.400 |
Therapeutic
|
group |
CTD_human |
Cellular toxicity induced by SRF-mediated transcriptional squelching.
|
17116645 |
2007 |