SRF, serum response factor, 6722

N. diseases: 147; N. variants: 1
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE There is mounting evidence that MRTFs and SRF represent promising targets for hepatocellular carcinoma (HCC) growth. 31844251 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE The identification of SRF/MCM7 complex as a target of ATO provides new insights into ATO's mechanism, which may benefit the appropriate use of this agent in the treatment of HCC. 31186405 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype. 28114277 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/actin signaling as a highly oncogenic driver mechanism for hepatocarcinogenesis. 25266280 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Expression of SRF and Snail were detected in 37.6% (55 of 146 cases) and in 12.3% (18 of 146 cases) of the HCCs, respectively. 24173109 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE High SRF expressing HCC tissues showed higher levels of expression of MMP-2 and MMP-9, compared with low SRF expressing HCC tissues. 21842128 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE In the HCC cell lines examined, siSRF797 reduced both the mRNA and protein levels of SRF without inducing unspecific interferon response or cytotoxicity. 20144681 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE The role of serum response factor in hepatocellular carcinoma: implications for disease progression. 20811705 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Co-labeling studies demonstrated exclusive localization of miR-122 in the benign livers, whereas SRF predominantly expressed in HCC. 19726678 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease RGD SRF may play an important role in the development of hepatocellular carcinoma in LEC rats by mediating the proto-oncogene c-fos induction. 9570363 1997